ArticleGut2002
Serrated adenoma in familial adenomatous polyposis: relation to germline APC gene mutation.
Article in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression.Cell discovery · 2023Article
- Importance of sessile serrated lesions in a patient with familial adenomatous polyposis.Clinical journal of gastroenterology · 2021Article
- Serrated adenomas with a BRAF mutation in a young patient with familial adenomatous polyposis.International journal of colorectal disease · 2020Article
- Isoperistaltic Jejunal Loop Interposition after Total Gastrectomy for Gastric Cancer in Patients with Familial Adenomatous Polyposis.Journal of gastric cancer · 2020Article
- Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing.Clinical and translational gastroenterology · 2019Article
- Molecular and Pathological Features of Gastric Cancer in Lynch Syndrome and Familial Adenomatous Polyposis.International journal of molecular sciences · 2018Article
- Frequent CpG island methylation: a risk factor in the progression of traditional serrated adenoma of the colorectum.International journal of clinical and experimental pathology · 2017Article
- Colonic polyposis syndromes--an experience from a tertiary centre in South India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Article
- Serrated adenomas.Current gastroenterology reports · 2009Article
- Sessile serrated polyps of the colorectum are rare in patients with Lynch syndrome and in familial colorectal cancer families.Familial cancer · 2008Article
- Serrated adenoma of the duodenum.Journal of clinical pathology · 2004Article
- Basic concepts for genetic testing in common hereditary colorectal cancer syndromes.Current gastroenterology reports · 2002Review
Corrections and comments
- Commented on by
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerrated adenoma is a precursor of colorectal cancer.
aimTo clarify possible genotype-phenotype correlations of serrated adenomas in familial adenomatous polyposis (FAP). PATIENTS: Eleven patients from eight families with FAP.
methodsWe performed total colonoscopy with multiple biopsies in patients. Neoplasia with a serrated glandular structure was regarded as a serrated adenoma. In each patient, germline mutations of the APC gene were determined. Colonic phenotype was compared with germline mutations of the APC gene.
resultsSerrated adenomas were found in three patients. These patients had macroscopic polyps <100 in number. Pedigrees with serrated adenomas had the truncating germline APC mutation at codon 161, 332, or 1556 while in the other pedigrees mutations were found between codons 554 and 1324.
conclusionsIn FAP, serrated adenoma may be a phenotype characteristic of the attenuated form.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.