ArticleBiological psychiatry2002
Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome.
Article in Biological psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Magnitude and heterogeneity of brain structural abnormalities in 22q11.2 deletion syndrome: a meta-analysis.Molecular psychiatry · 2020Pooled it
- Multimodal Brain Graph Analysis for Uncovering Path-Based Biomarkers in Schizophrenia: Integrating Static and Dynamic Approaches.Human brain mapping · 2026Article
- An uncommon neuroradiological finding of hippocampal malrotation in childhood onset schizophrenia and 22q11.2 Deletion Syndrome: a case report and a brief review of the literature.European child & adolescent psychiatry · 2025Review
- Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study.Molecular psychiatry · 2024Article
- Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation.Molecular psychiatry · 2023Article
- Mitochondrial genes in the 22q11.2 deleted region regulate neural stem and progenitor cell proliferation.bioRxiv : the preprint server for biology · 2023Article
- Distinct neuroanatomical and neuropsychological features of Down syndrome compared to related neurodevelopmental disorders: a systematic review.Frontiers in neuroscience · 2023Article
- Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size.Molecular psychiatry · 2020Article
- Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice.Nature communications · 2020Article
- The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour.Nature communications · 2019Article
- Validation of a microRNA target site polymorphism in H3F3B that is potentially associated with a broad schizophrenia phenotype.PloS one · 2018Article
- System-based proteomic and metabonomic analysis of the Df(16)AMolecular psychiatry · 2017Article
- Article
- Neural correlates of reward processing in adults with 22q11 deletion syndrome.Journal of neurodevelopmental disorders · 2016Article
- Neuronal migration abnormalities and its possible implications for schizophrenia.Frontiers in neuroscience · 2015Review
- A Synaptic Function Approach to Investigating Complex Psychiatric Diseases.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion.Molecular psychiatry · 2014Article
- Disrupted working memory circuitry and psychotic symptoms in 22q11.2 deletion syndrome.NeuroImage. Clinical · 2014Article
- Converging levels of analysis on a genomic hotspot for psychosis: insights from 22q11.2 deletion syndrome.Neuropharmacology · 2013Review
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
background22q11 Deletion Syndrome is a genetic syndrome associated with an increased risk for developing schizophrenia. Brain abnormalities have been reported in 22q11 Deletion Syndrome, but little is known about whether differences in brain structure underlie the psychotic disorders associated with this syndrome. In the current study, we used magnetic resonance imaging to characterize the structural brain abnormalities found in adults who have both 22q11 Deletion Syndrome and schizophrenia.
methodsMagnetic resonance imaging brain scans of 14 adults (7 male, 7 female) with 22q11 Deletion Syndrome and schizophrenia and 14 age- and gender-matched healthy volunteers were analyzed to derive measures of gray matter, white matter, and cerebrospinal fluid. Differences between the two groups were tested using student t tests.
results22q11 Deletion Syndrome and schizophrenia subjects had significantly smaller total gray matter volume (t = 2.88, p <.01) and larger lateral ventricles (t = 4.08, p <.001) than healthy controls. Gray matter deficits were most prominent in the frontal and temporal lobes. Total white matter volumes did not differ between the two groups.
conclusionsFindings from this 22q11 Deletion Syndrome and schizophrenia study are similar to those reported in other patients with schizophrenia, but only partially consistent with those reported in nonpsychotic children with 22q11 Deletion Syndrome. 22q11 Deletion Syndrome may provide a valuable genetic neurodevelopmental model for investigating the relationship between abnormalities in brain development and the expression of schizophrenia.
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