ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2002
RNA interference: advances and questions.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery.Frontiers in cell and developmental biology · 2022Review
- Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo.PLoS pathogens · 2021Article
- RNA-induced silencing attenuates G protein-mediated calcium signals.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion.Cell reports · 2014Article
- A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.Biochimica et biophysica acta · 2012Article
- Adaptor protein 2 regulates receptor-mediated endocytosis and cyst formation in Giardia lamblia.The Biochemical journal · 2010Article
- RNA interference in Trypanosoma brucei: role of the n-terminal RGG domain and the polyribosome association of argonaute.The Journal of biological chemistry · 2009Article
- Approaches for functional analysis of flagellar proteins in African trypanosomes.Methods in cell biology · 2009Article
- Characterization and developmentally regulated localization of the mitochondrial carrier protein homologue MCP6 from Trypanosoma brucei.Eukaryotic cell · 2006Article
- A divergent transcription factor TFIIB in trypanosomes is required for RNA polymerase II-dependent spliced leader RNA transcription and cell viability.Eukaryotic cell · 2006Article
- ATP synthase is responsible for maintaining mitochondrial membrane potential in bloodstream form Trypanosoma brucei.Eukaryotic cell · 2006Article
- Gene clusters for insecticidal loline alkaloids in the grass-endophytic fungus Neotyphodium uncinatum.Genetics · 2005Article
- RNA interference: a potent tool for gene-specific therapeutics.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2004Review
- Disruption of Ixodes scapularis anticoagulation by using RNA interference.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages.Journal of virology · 2003Article
- RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma brucei.Eukaryotic cell · 2003Article
- Biology and mechanism of trypanosome cell motility.Eukaryotic cell · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In animals and protozoa gene-specific double-stranded RNA triggers the degradation of homologous cellular RNAs, the phenomenon of RNA interference (RNAi). RNAi has been shown to represent a novel paradigm in eukaryotic biology and a powerful method for studying gene function. Here we discuss RNAi in terms of its mechanism, its relationship to other post-transcriptional gene silencing phenomena in plants and fungi, its connection to retroposon silencing and possibly to translation, and its biological role. Among the organisms where RNAi has been demonstrated the protozoan parasite Trypanosoma brucei represents the most ancient branch of the eukaryotic lineage. We provide a synopsis of what is currently known about RNAi in T. brucei and outline the recent advances that make RNAi the method of choice to disrupt gene function in these organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.