ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2002
Mining the Plasmodium genome database to define organellar function: what does the apicoplast do?
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Selection of an Aptamer against the Enzyme 1-deoxy-D-xylulose-5-phosphate Reductoisomerase fromPharmaceutics · 2022Article
- An Ecologically Framed Comparison of The Potential for Zoonotic Transmission of Non-Human and Human-Infecting Species of Malaria Parasite.The Yale journal of biology and medicine · 2021Review
- Annotation and characterization of Babesia gibsoni apicoplast genome.Parasites & vectors · 2020Article
- Comparative sequence analysis of Cyclospora cayetanensis apicoplast genomes originating from diverse geographical regions.Parasites & vectors · 2016Article
- Functional Analyses of the Toxoplasma gondii DNA Gyrase Holoenzyme: A Janus Topoisomerase with Supercoiling and Decatenation Abilities.Scientific reports · 2015Article
- What was the real contribution of endosymbionts to the eukaryotic nucleus? Insights from photosynthetic eukaryotes.Cold Spring Harbor perspectives in biology · 2014Review
- Peroxiredoxins in parasites.Antioxidants & redox signaling · 2012Review
- The apicomplexan plastid and its evolution.Cellular and molecular life sciences : CMLS · 2011Review
- David Roos. Interview by H. Craig Mak.Nature biotechnology · 2011Article
- Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites.Current topics in medicinal chemistry · 2011Review
- Carotenoid biosynthesis in intraerythrocytic stages of Plasmodium falciparum.The Journal of biological chemistry · 2009Article
- metaTIGER: a metabolic evolution resource.Nucleic acids research · 2009Article
- The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes.Genome biology · 2009Article
- Protein trafficking to the apicoplast: deciphering the apicomplexan solution to secondary endosymbiosis.Eukaryotic cell · 2007Review
- Molecular cloning of apicoplast-targeted Plasmodium falciparum DNA gyrase genes: unique intrinsic ATPase activity and ATP-independent dimerization of PfGyrB subunit.Eukaryotic cell · 2007Article
- Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?Malaria journal · 2006Review
- Structural and functional insights into the chloroplast ATP-dependent Clp protease in Arabidopsis.The Plant cell · 2006Article
- Functional characterization of a fatty acyl-CoA-binding protein (ACBP) from the apicomplexan Cryptosporidium parvum.Microbiology (Reading, England) · 2006Article
- Functional characterization of an evolutionarily distinct phosphopantetheinyl transferase in the apicomplexan Cryptosporidium parvum.Eukaryotic cell · 2005Article
- Receptor for retrograde transport in the apicomplexan parasite Toxoplasma gondii.Eukaryotic cell · 2005Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apicomplexan species constitute a diverse group of parasitic protozoa, which are responsible for a wide range of diseases in many organisms. Despite differences in the diseases they cause, these parasites share an underlying biology, from the genetic controls used to differentiate through the complex parasite life cycle, to the basic biochemical pathways employed for intracellular survival, to the distinctive cell biology necessary for host cell attachment and invasion. Different parasites lend themselves to the study of different aspects of parasite biology: Eimeria for biochemical studies, Toxoplasma for molecular genetic and cell biological investigation, etc. The Plasmodium falciparum Genome Project contributes the first large-scale genomic sequence for an apicomplexan parasite. The Plasmodium Genome Database (http://PlasmoDB.org) has been designed to permit individual investigators to ask their own questions, even prior to formal release of the reference P. falciparum genome sequence. As a case in point, PlasmoDB has been exploited to identify metabolic pathways associated with the apicomplexan plastid, or 'apicoplast' - an essential organelle derived by secondary endosymbiosis of an alga, and retention of the algal plastid.
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