ReviewSports medicine (Auckland, N.Z.)2002
The unknown mechanism of the overtraining syndrome: clues from depression and psychoneuroimmunology.
Review in Sports medicine (Auckland, N.Z.), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 7 syntheses or guidelines pooled it, 358 citations in OpenAlex.
- Pickleball and mental health in adults: A systematic review.Frontiers in psychology · 2023Pooled it
- Lymphocyte and dendritic cell response to a period of intensified training in young healthy humans and rodents: A systematic review and meta-analysis.Frontiers in physiology · 2022Pooled it
- Exercise Frequency Determines Heart Rate Variability Gains in Older People: A Meta-Analysis and Meta-Regression.Sports medicine (Auckland, N.Z.) · 2019Pooled it
- Biomarkers of Physiological Responses to Periods of Intensified, Non-Resistance-Based Exercise Training in Well-Trained Male Athletes: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2018Pooled it
- Monitoring the athlete training response: subjective self-reported measures trump commonly used objective measures: a systematic review.British journal of sports medicine · 2016Pooled it
- Pooled it
- Sport psychiatry: a systematic review of diagnosis and medical treatment of mental illness in athletes.Sports medicine (Auckland, N.Z.) · 2010Pooled it
- Evaluating the Impact of Probiotic Therapy on the Endocannabinoid System, Pain, Sleep and Fatigue: A Randomized, Double-Blind, Placebo-Controlled Trial in Dancers.International journal of molecular sciences · 2024Trial
- Ketone ester supplementation blunts overreaching symptoms during endurance training overload.The Journal of physiology · 2019Trial
- The Impact of Overtraining on Anxiety-Like Behavior and Tight Junction Proteins of the Blood-Brain Barrier in Mice.Brain and behavior · 2026Article
- The Influence of Exercise on the Endocrine System: Impacts on Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- Exploring the interrelationships between athlete burnout, depression, and anxiety: a network analysis approach.Frontiers in psychology · 2026Article
- Article
- Exercise Intervention in Autonomic Function, Immunity, and Cardiovascular Health: A Precision Medicine Approach.Journal of cardiovascular development and disease · 2025Review
- Inflammation and depression: an evolutionary framework for the role of physical activity and exercise.Frontiers in psychology · 2025Review
- The association of physical activity and leisure-time sedentary behavior with perceived stress among Chinese adults: A cross-sectional study based on the Chinese health and nutrition survey data.Preventive medicine reports · 2024Article
- Changes in the hormonal and inflammatory profile of young sprint- and endurance-trained athletes following a sports camp: a nonrandomized pretest-posttest study.BMC sports science, medicine & rehabilitation · 2024Article
- Monitoring training, performance, biomarkers, and psychological state throughout a competitive season: a case study of a triathlete.European journal of applied physiology · 2024Article
- A Narrative Review on Adipose Tissue and Overtraining: Shedding Light on the Interplay among Adipokines, Exercise and Overtraining.International journal of molecular sciences · 2024Review
- The reproducibility of dendritic cell and T cell counts to a 30-min high-intensity cycling protocol as a tool to highlight overtraining.Experimental physiology · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When prolonged, excessive training stresses are applied concurrent with inadequate recovery, performance decrements and chronic maladaptations occur. Known as the overtraining syndrome (OTS), this complex condition afflicts a large percentage of athletes at least once during their careers. There is no objective biomarker for OTS and the underlying mechanism is unknown. However, it is not widely recognised that OTS and clinical depression [e.g. major depression (MD)] involve remarkably similar signs and symptoms, brain structures, neurotransmitters, endocrine pathways and immune responses. We propose that OTS and MD have similar aetiologies. Our examination of numerous shared characteristics offers insights into the mechanism of OTS and encourages testable experimental hypotheses. Novel recommendations are proposed for the treatment of overtrained athletes with antidepressant medications, and guidelines are provided for psychological counselling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.