ArticleDigestive diseases and sciences2002
Attenuated apoptosis in H. pylori-colonized gastric mucosa of Mongolian gerbils in comparison with mice.
Article in Digestive diseases and sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Development of an animal model of Helicobacter pylori (Indian strain) infection.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
- Dietary factors modulate Helicobacter-associated gastric cancer in rodent models.Toxicologic pathology · 2014Article
- Short-term celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model.World journal of gastroenterology · 2009Article
- Helicobacter pylori eradication shifts monocyte Fcgamma receptor balance toward inhibitory FcgammaRIIB in immune thrombocytopenic purpura patients.The Journal of clinical investigation · 2008Article
- Effects of leptin on stress-induced changes of caspases in rat gastric mucosa.Journal of gastroenterology · 2007Article
- Salt and stress synergize H. pylori-induced gastric lesions, cell proliferation, and p21 expression in Mongolian gerbils.Digestive diseases and sciences · 2007Article
- Helicobacter pylori: present status and future prospects in Japan.Journal of gastroenterology · 2007Review
- Helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis.World journal of gastroenterology · 2005Review
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Authors and funding
9 authors at 5 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Although gastric cancer formation with H. pylori in Mongolian gerbils was recently reported, the same inoculation procedure did not result in cancer formation in other animals such as mice. Disturbed regulation of apoptosis and cell proliferation are known to link the multistep process of carcinogenesis. The present study is designed to examine the level of gastric epithelial cell apoptosis in Mongolian gerbils colonized with the H. pylori (Sydney strain: SS1) in comparison with that in mice. Mice (C57BL/6) and Mongolian gerbils were orally inoculated with SS1 and the stomachs were examined 9 and 18 months later. MPO activity increased persistently in gerbils, but increased transiently in mice. While the levels of DNA fragmentation, caspase-3 activity, and the number of TUNEL-positive cells increased significantly in mice, such parameters were attenuated in gerbils. On the other hand, the number of PCNA-positive cells increased after SS1 inoculation only in Mongolian gerbils, suggesting the enhancement of cell turnover in H. pylori-colonized gerbils. In conclusion, the SS1-induced increase in gastric mucosal apoptosis observed in mice was attenuated significantly in Mongolian gerbils, suggesting the causative role for the higher incidence of gastric carcinogenesis in this animal.
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