ArticleDigestive diseases and sciences2002
Helicobacter pylori infection and oncogene expressions in gastric carcinoma and its precursor lesions.
Article in Digestive diseases and sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- RIP140 and LCoR expression in gastrointestinal cancers.Oncotarget · 2017Article
- Clinical and prognosis relevance of COX-2 expression in Tunisian patients with primary gastric adenocarcinoma.Cancer biomarkers : section A of Disease markers · 2016Article
- Genetic and molecular aspects of Helicobacter pylori in gastritis, pre- cancerous conditions and gastric adenocrcinoma.Gastroenterology and hepatology from bed to bench · 2015Review
- Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.The Indian journal of medical research · 2012Article
- Ectopic expression of guanylyl cyclase C and endogenous ligand guanylin correlates significantly with Helicobacter pylori infection in gastric carcinogenesis.Medical oncology (Northwood, London, England) · 2012Article
- hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions.BMC gastroenterology · 2012Article
- Molecular assessment of c-H-ras p21 expression in Helicobacter pylori-mediated gastric carcinogenesis.Molecular and cellular biochemistry · 2012Article
- Long-term use of nonsteroidal anti-inflammatory drugs normalizes the kinetics of gastric epithelial cells in patients with Helicobacter pylori infection via attenuation of gastric mucosal inflammation.Journal of gastroenterology · 2009Article
- Signal transduction proteins in tumors from Puerto Rican and Caucasian gastric adenocarcinoma patients: expression differences with potential for specific targeted therapies.Digestive diseases and sciences · 2008Article
- Lack of CD117 and rare bcl-2 expression in stomach cancer by immunohistochemistry. An immunohistochemical study with review of the literature.Diagnostic pathology · 2006Article
- Genetic alterations in benign lesions: chronic gastritis and gastric ulcer.World journal of gastroenterology · 2006Article
- Effect of Helicobacter pylori infection on Bax protein expression in patients with gastric precancerous lesions.World journal of gastroenterology · 2005Article
- Detection and location of Helicobacter pylori in human gastric carcinomas.World journal of gastroenterology · 2005Article
- Coordinate increase of telomerase activity and c-Myc expression in Helicobacter pylori-associated gastric diseases.World journal of gastroenterology · 2004Article
- Molecule action mechanisms of NM-3 on human gastric cancer SGC-7901 cells in vivo or in vitro.World journal of gastroenterology · 2003Article
- Effect of Helicobacter pylori on apoptosis and apoptosis related genes in gastric cancer cells.Molecular pathology : MP · 2003Article
- Biological markers in Helicobacter pylori-associated gastritis and carcinoma: the value of a scoring system.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although it is fairly well accepted that Helicobacter pylori infection plays a significant role in causing gastric cancer, the exact mechanisms involved in its pathogenesis are unclear. We have examined the relationship between H. pylori infection and oncogene expression in different stages of disease progression from precursor lesions to gastric carcinoma. We used Diff-Quik stain to diagnose H. pylori infection and immunohistochemical stains against c-erbB-2, p53, ras, c-myc, and bcl-2 to determine expression of oncogenes. H. pylori infection was found in all cases of chronic gastritis, atrophic gastritis, intestinal metaplasia, and early gastric carcinoma, and in 16 of 30 (53%) cases of advanced gastric carcinoma. Overexpression of c-erbB-2 was found in 2 (7%) cases of advanced gastric carcinoma, which were H. pylori negative. Suppressor gene, p53, was overexpressed in 3 (30%) cases of intestinal metaplasia, 2 (33%) cases of early gastric carcinoma, and 18 (60%) cases of advanced gastric carcinoma. Of these 18 p53-positive advanced gastric cancer cases, 11 (61%) were H. pylori positive. Expression of ras p21 was found in 4 (40%) cases of H. pylori-negative normal mucosa, 10 (100%) cases of chronic gastritis, 1 (10%) case of atrophic mucosa, 6 (60%) cases of intestinal metaplasia, 2 (33%) cases of nonneoplastic mucosa adjacent to early gastric carcinoma, and 7 (23%) nonneoplastic mucosa adjacent to advanced gastric carcinoma, all of which showed H. pylori. No evidence of expression of either c-myc or bcl-2 was detected in any of the above-mentioned samples. The data suggest that H. pylori infection may increase expression of ras p21 proteins and induce p53 suppressor gene mutation early in the process of gastric carcinogenesis.
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