ArticleAmerican journal of human genetics2002
Phylogeographic differentiation of mitochondrial DNA in Han Chinese.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.
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Who cites it
175 citing papers in PubMed.
- Mitochondrial DNA haplogroup confers genetic susceptibility to nasopharyngeal carcinoma in Chaoshanese from Guangdong, China.PloS one · 2014Trial
- Genetic origin and forensic analysis of han populations from four districts in Shanghai, China, based on Y-chromosome STR and SNP markers.International journal of legal medicine · 2026Article
- Mitochondrial DNA Haplogroups Influence Oxidative Stress Profiles and Susceptibility to Metabolic Syndrome in an Asian Population.Antioxidants (Basel, Switzerland) · 2026Article
- Genetic structure and admixture of the Yi and Qiang in southwestern China.Journal of Zhejiang University. Science. B · 2026Article
- Modern and Ancient Genomes Reveal Neolithic Paternal Expansions of Millet and Rice Farmers and Demic Diffusion from China into Mainland Southeast Asia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Maternal genetic structure and population affinities of the Sichuan Han Chinese based on whole mitochondrial genomes.BMC genomics · 2026Article
- Article
- Genetic insights into the origin, admixture, and migration of the early Austronesian peoples.Journal of human genetics · 2026Review
- Demographic history of the Jomon people: insights from whole-mitogenome analysis.Anthropological science : journal of the Anthropological Society of Nippon = Jinruigaku zasshi · 2026Article
- YanHuang Paternal Genomic Resource Suggests A Weakly-differentiated Multi-source Admixture in the Formation of Han Founding Ancestral Lineages.Genomics, proteomics & bioinformatics · 2025Article
- Associations between peripheral blood mitochondrial genomic variants and gestational diabetes mellitus and postpartum abnormal glucose metabolism.Journal of diabetes investigation · 2025Article
- Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm.Science China. Life sciences · 2025Review
- Risk Factors Associated With Leber Hereditary Optic Neuropathy due to Rare Mutations in Mitochondrial DNA-Encoded Respiratory Complex I Subunits.Clinical genetics · 2025Review
- The Potential Protective Role of Mitochondrial Haplogroup R in Ovarian Response: An Exploratory Study.International journal of molecular sciences · 2025Article
- High prevalence of m.1555A > G in patients with hearing loss in the Baikal Lake region of Russia as a result of founder effect.Scientific reports · 2024Article
- Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease.Aging cell · 2024Article
- Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources.BMC genomics · 2024Article
- Whole mitochondrial genome analyses of Han population from Shandong of China using massively parallel sequencing.Frontiers in genetics · 2024Article
- Association of mitochondrial DNA variation with high myopia in a Han Chinese population.Molecular genetics and genomics : MGG · 2023Article
- Is there a mitochondrial DNA haplogroup connection between osteoarthritis and elite athletes? A narrative review.RMD open · 2022Review
115 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
To characterize the mitochondrial DNA (mtDNA) variation in Han Chinese from several provinces of China, we have sequenced the two hypervariable segments of the control region and the segment spanning nucleotide positions 10171-10659 of the coding region, and we have identified a number of specific coding-region mutations by direct sequencing or restriction-fragment-length-polymorphism tests. This allows us to define new haplogroups (clades of the mtDNA phylogeny) and to dissect the Han mtDNA pool on a phylogenetic basis, which is a prerequisite for any fine-grained phylogeographic analysis, the interpretation of ancient mtDNA, or future complete mtDNA sequencing efforts. Some of the haplogroups under study differ considerably in frequencies across different provinces. The southernmost provinces show more pronounced contrasts in their regional Han mtDNA pools than the central and northern provinces. These and other features of the geographical distribution of the mtDNA haplogroups observed in the Han Chinese make an initial Paleolithic colonization from south to north plausible but would suggest subsequent migration events in China that mainly proceeded from north to south and east to west. Lumping together all regional Han mtDNA pools into one fictive general mtDNA pool or choosing one or two regional Han populations to represent all Han Chinese is inappropriate for prehistoric considerations as well as for forensic purposes or medical disease studies.
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