ArticleOccupational and environmental medicine2002
Influence of solvent exposure and aging on cognitive functioning: an 18 year follow up of formerly exposed floor layers and their controls.
Article in Occupational and environmental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 58 citations in OpenAlex.
- The Chemical Exposome of Human Aging.Frontiers in genetics · 2020Review
- Chronic solvent-induced encephalopathy: course and prognostic factors of neuropsychological functioning.International archives of occupational and environmental health · 2018Article
- Evaluation of occupational exposure to different levels of mixed organic solvents and cognitive function in the painting unit of an automotive industry.Health promotion perspectives · 2018Article
- Can Neglected Tropical Diseases Compromise Human Wellbeing in Sex-, Age-, and Trait-Specific Ways?PLoS neglected tropical diseases · 2016Review
- Background Noise Contributes to Organic Solvent Induced Brain Dysfunction.Neural plasticity · 2016Article
- Time may not fully attenuate solvent-associated cognitive deficits in highly exposed workers.Neurology · 2014Article
- Assessment of neuro behavioral disorders in workers exposed to organic solvents in a publication house.Medical journal of the Islamic Republic of Iran · 2014Article
- Can intensive use of alcohol-based hand rubs lead to passive alcoholization?International journal of environmental research and public health · 2010Review
- Occupational exposure to solvents and cognitive performance in the GAZEL cohort: preliminary results.Dementia and geriatric cognitive disorders · 2010Article
- Self-reported symptoms and their effects on cognitive functioning in workers with past exposure to solvent-based glues: an 18-year follow-up.International archives of occupational and environmental health · 2007Article
- Solvent neurotoxicity.Occupational and environmental medicine · 2006Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo extend our knowledge of how exposure to neurotoxic substances during working life affects cognitive functioning in the long term. Does long term occupational exposure to organic solvents lead to aggravated cognitive impairment later in life?
methodsA follow up was conducted of floor layers exposed to solvents and their unexposed referents (carpenters) 18 years after the baseline assessment. The pattern of cognitive changes in the two groups was compared, with the same 10 neuropsychological tests from the test battery for investigating functional disorders (TUFF) that were used at baseline. The study included 41 floor layers and 40 carpenters. A medical examination focused on health at the present and during the past 18 years. An extensive exposure assessment made in the initial study included questionnaires, interviews, and measurements. Additional exposure during the follow up period was minor, as explored in interviews at follow up.
resultsThe entire group of floor layers did not deteriorate significantly more over time than did the carpenters. However, among the oldest subjects (>60 years), only floor layers showed decline in visual memory. Moreover, the most highly exposed floor layers deteriorated significantly more than their referents in visual memory and perceptual speed, and they tended to display larger decrements in motor speed. Significant dose effect relations were found; higher cumulative exposure was associated with decrements in visual episodic memory, perceptual speed and attention, and visuospatial skill.
conclusionsThe hypothesis that floor layers would deteriorate more in cognitive performance than their unexposed referents over a period of 18 years was partly supported by the results of this study. The results are consistent with the view that the negative effects of exposure to solvents may interact with the normal aging process, primarily at heavy exposure.
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