ArticleMolecular pathology : MP2002
Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia.
Article in Molecular pathology : MP, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 55 citations in OpenAlex.
- A Phase I/II Study of the mTOR Inhibitor Everolimus in Combination with HyperCVAD Chemotherapy in Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Trial
- Increased risk of leukaemia in children with Down syndrome: a somatic evolutionary view.Expert reviews in molecular medicine · 2021Article
- CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis.Journal of cell communication and signaling · 2021Review
- Cloning, molecular characterization, and tissue differential expression of connective tissue growth factor (ctgf) of grass carp.Fish physiology and biochemistry · 2019Article
- Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57.Experimental hematology · 2016Article
- Effects of insulin-like growth factor-1 on B-cell precursor acute lymphoblastic leukemia.International journal of hematology · 2013Article
- Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2.Molecular cancer therapeutics · 2012Article
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- Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program.Pediatric blood & cancer · 2011Article
- AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia.Journal of molecular signaling · 2010Article
- LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor.Journal of cell science · 2009Article
- Pediatric developmental therapies: interesting new drugs now in early-stage clinical trials.Current oncology reports · 2008Review
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- Article
- Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis.The Biochemical journal · 2006Review
- Elevated serum insulin-like growth factor binding protein-2 is associated with a high relapse risk after hematopoietic stem cell transplantation in childhood AML.Bone marrow transplantation · 2006Article
- Insulin-like growth factor-binding protein 4 in children with acute lymphoblastic leukemia.International journal of hematology · 2005Article
- A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis.Cancer cell international · 2003Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlterations in the insulin-like growth factor (IGF) system have been reported for different tumours. They are of particular interest in the search for new prognostic and therapeutic approaches in cancer. In childhood acute lymphoblastic leukaemia (ALL) the amount of "tumour mass" at diagnosis can exceed 1 kg. To understand the endocrine, paracrine, and autocrine potential of the malignant transformed progenitor cells, the ability of these cells to express components of the IGF system needs to be investigated.
aimTo characterise the expression pattern of genes of the IGF system in malignant lymphoblasts of children suffering from ALL.
methodsReverse transcription polymerase chain reaction of Ficoll separated mononuclear cells from 142 children with ALL, 127 cord blood samples, and 55 blood samples of age matched controls were studied.
resultsThe expression of IGF-I, IGF-II, IGF binding protein 5 (IGFBP-5), and CTGF (IGFBP-rP2) was seen in a higher proportion of mononuclear cells of patients with ALL than in controls. Patients with ALL who were in continuous remission had a lower percentage of IGFBP-2 and IGFBP-3 expressing mononuclear cells at diagnosis than did those who developed a relapse. Only malignant lymphoblasts of B cell origin showed expression of CTGF (IGFBP-rP2). Malignant lymphoblasts of T cell origin more often expressed IGFBP-2 and IGFBP-5, whereas IGF-II and IGFBP-3 expression was seen more often in lymphoblasts of B cell origin.
conclusionsMalignant lymphoblasts of patients with ALL express components of the IGF system and therefore promote their own growth in an autocrine, paracrine, or endocrine manner. Whether these components will be useful as prognostic factors in the stratification of ALL treatment in children needs to be evaluated.
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