ArticleJournal of virology2002
PrP expression and replication by Schwann cells: implications in prion spreading.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 80 citations in OpenAlex.
- "Polyradiculoneuritis" as an Atypical Clinical Presentation of Creutzfeldt-Jakob Disease: A Case Report and Review of Literature.Life (Basel, Switzerland) · 2026Article
- Sciatic Integrity Is Necessary for Fast and Efficient Scrapie Infection After Footpad Injection.International journal of molecular sciences · 2025Article
- Demyelinating neuropathy as the initial presentation of familial E200K Creutzfeldt-Jakob disease in two patients.Annals of clinical and translational neurology · 2025Article
- Review
- Genetically engineered cellular models of prion propagation.Cell and tissue research · 2023Review
- Transport of Prions in the Peripheral Nervous System: Pathways, Cell Types, and Mechanisms.Viruses · 2022Review
- Propagation and Dissemination Strategies of Transmissible Spongiform Encephalopathy Agents in Mammalian Cells.International journal of molecular sciences · 2022Review
- From Cell Culture to Organoids-Model Systems for Investigating Prion Strain Characteristics.Biomolecules · 2021Review
- An astrocyte cell line that differentially propagates murine prions.The Journal of biological chemistry · 2020Article
- Flow Cytometric Detection of PrPJournal of virology · 2018Article
- Physiological Functions of the Cellular Prion Protein.Frontiers in molecular biosciences · 2017Review
- Article
- Article
- Myelin damage due to local quantitative abnormalities in normal prion levels: evidence from subacute combined degeneration and multiple sclerosis.Journal of neurology · 2014Review
- Cellular aspects of prion replication in vitro.Viruses · 2013Review
- Infectious prions accumulate to high levels in non proliferative C2C12 myotubes.PLoS pathogens · 2013Article
- Detection of disease-associated prion protein in the optic nerve and the adrenal gland of cattle with bovine spongiform encephalopathy by using highly sensitive immunolabeling procedures.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- Prion replication in the hematopoietic compartment is not required for neuroinvasion in scrapie mouse model.PloS one · 2010Article
- Dramatic reduction of PrP C level and glycosylation in peripheral nerves following PrP knock-out from Schwann cells does not prevent transmissible spongiform encephalopathy neuroinvasion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- PrP expression, PrPSc accumulation and innervation of splenic compartments in sheep experimentally infected with scrapie.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prion infection relies on a continuous chain of PrP(c)-expressing tissues to spread from peripheral sites to the central nervous system (CNS). Direct neuroinvasion via peripheral nerves has long been considered likely. However, the speed of axonal flow is incompatible with the lengthy delay prior to the detection of PrP(Sc) in the brain. We hypothesized that Schwann cells could be the candidate implicated in this mechanism; for that, it has to express PrP(c) and to allow PrP(Sc) conversion. We investigated in vivo localization of PrP(c) in sciatic nerve samples from different strains of mice. We demonstrated that PrP(c) is mainly localized at the cell membrane of the Schwann cell. We also studied in vitro expression of PrP(c) in the Schwann cell line MSC-80 and demonstrated that it expresses PrP(c) at the same location. More specifically, we demonstrated that this glial cell line, when infected in vitro with the mouse Chandler prion strain, both produces the PrP(Sc) till after 18 passages and is able to transmit disease to mice, which then develop the typical signs of prion diseases. It is the first time that infection and replication of PrP(Sc) are shown in a peripheral glial cell line.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.