ArticleEnvironmental health perspectives2002
Protein kinase C activity and the relations between blood lead and neurobehavioral function in lead workers.
Article in Environmental health perspectives, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Role of environmental toxicants in the development of hypertensive and cardiovascular diseases.Toxicology reports · 2022Review
- The Effect of Lead Exposure on Autism Development.International journal of molecular sciences · 2021Review
- Positive and inverse correlation of blood lead level with erythrocyte acetylcholinesterase and intelligence quotient in children: implications for neurotoxicity.Interdisciplinary toxicology · 2019Article
- Lead (Pb) exposure induces dopaminergic neurotoxicity inToxicology reports · 2019Article
- Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach.Metallomics : integrated biometal science · 2016Review
- Reconsideration of the WHO NCTB strategy and test selection.Neurotoxicology · 2014Article
- Serum trace metal levels in Alzheimer's disease and normal control groups.American journal of Alzheimer's disease and other dementias · 2014Article
- Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C.Neurotoxicology · 2010Article
- Mechanisms of lead-induced hypertension and cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2008Review
- Adult lead exposure: time for change.Environmental health perspectives · 2007Review
- Differential effects of lead exposure on components of verbal memory.Occupational and environmental medicine · 2005Article
- Neurotoxic effects and biomarkers of lead exposure: a review.Reviews on environmental healthReview
- Developmental lead exposure and adult criminal behavior: A 30-year prospective birth cohort study.Neurotoxicology and teratologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
At picomolar concentrations, lead activates protein kinase C (PKC). This activation has been implicated in the neurotoxicity of lead. No prior study has evaluated the association of PKC activity with neurobehavioral function in humans. The purpose of this study was to determine whether PKC activity is associated with neurobehavioral function or modifies the relationship between blood lead levels and neurobehavioral test scores. In this cross-sectional study of 212 current lead workers in the Republic of Korea, we assessed blood lead levels, neurobehavioral test scores, and PKC activity. PKC activity was determined by measuring the levels of phosphorylation of three erythrocyte membrane proteins (spectrin and the 52-kDa and 48-kDa subunits of band 4.9), using an in vitro back-phosphorylation assay. When linear regression was used to control for confounding variables, blood lead was a significant predictor of decrements in performance on tests of psychomotor function, manual dexterity, and executive ability. In linear regression models, back-phosphorylation levels were not associated with neurobehavioral test scores, but when dichotomized at the median, back-phosphorylation levels modified the relationship between blood lead and test scores. For spectrin and the 52-kDa and 48-kDa subunits of band 4.9, 5, 2, and 5 of 14 interaction terms, respectively, had associated p-values less than 0.10, all with positive signs, indicating that blood lead was associated with worse test scores only in subjects with lower back-phosphorylation levels. These data indicate that blood lead levels are associated with decrements in neurobehavioral test scores, mainly in the domains of manual dexterity and psychomotor function, but only in subjects with lower in vitro back-phosphorylation levels, which is equivalent to higher in vivo PKC activity. We hypothesize that subjects with higher PKC activity in the presence of lead may be more susceptible to the health effects of lead.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.