ArticleBritish journal of pharmacology2002
Distribution of alpha-1 adrenoceptor subtypes in RNA and protein in rabbit eyes.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- The effects of two systemic alpha1-adrenergic blockers on pupil diameter: a prospective randomized single-blind study.Naunyn-Schmiedeberg's archives of pharmacology · 2007Trial
- Adrenoceptors in the Eye - Physiological and Pathophysiological Relevance.Handbook of experimental pharmacology · 2024Review
- β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases-Historical Aspects and Nowadays Understanding.International journal of molecular sciences · 2023Review
- αInternational journal of molecular sciences · 2023Review
- The Selective α1 Antagonist Tamsulosin Alters ECM Distributions and Cellular Metabolic Functions of ARPE 19 Cells in a Concentration-Dependent Manner.Bioengineering (Basel, Switzerland) · 2022Article
- Risk of intraoperative floppy iris syndrome among selective alpha-1 blockers-A consistency model of 6,488 cases.Frontiers in medicine · 2022Article
- Comparison of effects of tamsulosin and silodosin on subfoveal choroidal thickness and pupil size diameters in patients with prostatic hyperplasia.International ophthalmology · 2021Article
- Improvement in Near Vision Following Silodosin Treatment in Patients With Lower Urinary Tract Symptoms.International neurourology journal · 2021Article
- Changes in Choroidal Component Ratio and Circulation After Coffee Intake in Healthy Subjects.Investigative ophthalmology & visual science · 2021Article
- The Role of Adrenoceptors in the Retina.Cells · 2020Review
- Functional-Optical Coherence Tomography: A Non-invasive Approach to Assess the Sympathetic Nervous System and Intrinsic Vascular Regulation.Frontiers in physiology · 2019Article
- Evaluation of Anterior Segment Changes of Patients Taking Alpha1-Blockers by Ultrasound Biomicroscopy in the Drug-free Period.Turkish journal of ophthalmology · 2017Article
- Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Intraoperative floppy iris syndrome in Indian population: a prospective study on incidence, risk factors, and impact on operative performance.Indian journal of ophthalmology · 2014Article
- Effect of tamsulosin on iris vasculature and morphology.Journal of cataract and refractive surgery · 2014Article
- Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.The Journal of clinical investigation · 2013Article
- Cataract surgery in patients taking alpha-1 antagonists: know the risks, avoid the complications.Deutsches Arzteblatt international · 2012Review
- Alpha-blockers and intraoperative floppy iris syndrome: ophthalmic adverse events following cataract surgery.Current urology reports · 2010Article
- Intraoperative floppy iris syndrome: pathophysiology, prevention, and treatment.Transactions of the American Ophthalmological Society · 2009Article
- Expression of distinct alpha 1-adrenoceptor phenotypes in the iris of pigmented and albino rabbits.British journal of pharmacology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated subtypes of alpha-1 adrenoceptor (AR) in rabbit ocular tissues using reverse transcription-polymerase chain reaction (RT - PCR), in situ hybridization (ISH) and binding studies. Competitive RT - PCR assays specific for the subtypes of alpha-1 AR revealed that the mRNA expression of alpha-1a AR was dominant, and that of each alpha-1b and alpha-1d was less than 10% and 0.5% of total alpha-1 ARs mRNA, respectively, in the iris, ciliary body, choroid and retina. In alpha-1a AR splice isoform-specific RT - PCR assays, we found a distinct proportion of each isoform mRNA in the iris, ciliary body and choroid. The results of the ISH assays for alpha-1a AR subtype showed that hybridization signals were clearly observed in the iris dilator muscle and in the epithelium of the ciliary processes. In binding studies, alpha-1A AR was a dominant subtype in the iris, choroid and retina in contrast to the ciliary body that had more alpha-1B than alpha-1A AR subtype at protein level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.