ArticleWorld journal of gastroenterology2002
Differential display of vincristine-resistance-related genes in gastric cancer SGC7901 cell.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Intravenous chemotherapy for resected gastric cancer: meta-analysis of randomized controlled trials.World journal of gastroenterology · 2002Pooled it
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- Downregulation of RPL6 by siRNA inhibits proliferation and cell cycle progression of human gastric cancer cell lines.PloS one · 2011Article
- Identification of triosephosphate isomerase as an anti-drug resistance agent in human gastric cancer cells using functional proteomic analysis.Journal of cancer research and clinical oncology · 2008Article
- Differential gene expression in benznidazole-resistant Trypanosoma cruzi parasites.Antimicrobial agents and chemotherapy · 2005Article
- Construction of prokaryotic expression system of 2 148-bp fragment from cagA gene and detection of cagA gene, CagA protein in Helicobacter pylori isolates and its antibody in sera of patients.World journal of gastroenterology · 2004Article
- Construction of prokaryotic expression system of ureB gene from a clinical Helicobacter pylori strain and identification of the recombinant protein immunity.World journal of gastroenterology · 2004Article
- Construction of a prokaryotic expression system of vacA gene and detection of vacA gene, VacA protein in Helicobacter pylori isolates and ant-VacA antibody in patients' sera.World journal of gastroenterology · 2004Article
- Effects of vitamin E succinate on the expression of Fas and PCNA proteins in human gastric carcinoma cells and its clinical significance.World journal of gastroenterology · 2004Article
- Establishment of Helicobacter pylori infection model in Mongolian gerbils.World journal of gastroenterology · 2004Article
- Apoptosis of human gastric adenocarcinoma cells induced by beta-ionone.World journal of gastroenterology · 2004Article
- Inhibition of beta-ionone on SGC-7901 cell proliferation and upregulation of metalloproteinases-1 and -2 expression.World journal of gastroenterology · 2004Article
- Construction and identification of recombinant vectors carrying herpes simplex virus thymidine kinase and cytokine genes expressed in gastric carcinoma cell line SGC7901.World journal of gastroenterology · 2004Article
- Construction of expression systems for flaA and flaB genes of Helicobacter pylori and determination of immunoreactivity and antigenicity of recombinant proteins.World journal of gastroenterology · 2003Article
- Construction of hpaA gene from a clinical isolate of Helicobacter pylori and identification of fusion protein.World journal of gastroenterology · 2003Article
- A gene encoding an apurinic/apyrimidinic endonuclease-like protein is up-regulated in human gastric cancer.World journal of gastroenterology · 2003Article
- Development of an oral DNA vaccine against MG7-Ag of gastric cancer using attenuated salmonella typhimurium as carrier.World journal of gastroenterology · 2003Article
- Effect of ZNRD1 gene antisense RNA on drug resistant gastric cancer cells.World journal of gastroenterology · 2003Article
- A novel gene, GCRG224, is differentially expressed in human gastric mucosa.World journal of gastroenterology · 2003Article
- Angiostatin up-regulation in gastric cancer cell SGC7901 inhibits tumorigenesis in nude mice.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo isolate and clone the vincristine-resistance-related genes in gastric cancer SGC7901 cell line and to clarify the multidrug-resistant molecular mechanism of gastric cancer cells.
methodsThe modified differential-display polymerase chain reaction (DD-PCR) was used to examine differences in the mRNA composition of Vincristine-resistant gastric cancer SGC 7901 cells (SGC7901/VCR), induced by vincristine sulfate versus SGC7901cells. The differentially expressed cDNA fragments were confirmed by reverse Northern analysis, sequencing, BLAST analysis and Northern bolt analysis.
resultsThe DD-PCR identified that 54 cDNA fragments were preferentially expressed in SGC 7901/VCR cells. When these cDNA fragments were analyzed by reverse Northern blot, twenty were reproducibly expressed at high level in SGC7901/VCR. Sequencing and BLAST analysis revealed that seven of the genes were known genes:ADP-ribosylation factor 4, Cytochrome oxidase subunit II, Ss-A/Ro ribonucleoprtein autoantigen 60kd subunit,ribosomal protein S13, galaectin-8 gene, oligophrenin 1 mRNA, ribosomal protein L23 mRNA; thirteen of the genes were unknown genes. The length and abundance of the four unknown genes were further confirmed by Northern blot analysis.
conclusionThe twenty differential known and unknown genes may be related to the vincristine-resistant mechanism in human gastric cancer SGC7901 cell line.
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