ArticleAmerican journal of human genetics2002
Localization of a susceptibility gene for common forms of stroke to 5q12.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis.BMC cardiovascular disorders · 2024Pooled it
- Association between phosphodiesterase 4D gene and ischaemic stroke.Journal of neurology, neurosurgery, and psychiatry · 2006Pooled it
- An rs4705342 T>C polymorphism in the promoter of miR-143/145 is associated with a decreased risk of ischemic stroke.Scientific reports · 2016Trial
- TTC7B emerges as a novel risk factor for ischemic stroke through the convergence of several genome-wide approaches.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Trial
- Review
- Single-nucleotide polymorphism rs2910829 inOpen life sciences · 2024Article
- Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis.Neuroradiology · 2022Article
- Associations between SNP83 of phosphodiesterase 4D gene and carotid atherosclerosis in a southern Chinese Han population: a case-control study.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- Pathophysiology of Lacunar Stroke: History's Mysteries and Modern Interpretations.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Review
- A meta-analysis of PDE-gene polymorphism and cerebral infarction risk.Experimental and therapeutic medicine · 2017Article
- Alpha-1 antitrypsin dysfunction and large artery stroke.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Association of GWAS-Supported Variants rs556621 on Chromosome 6p21.1 with Large Artery Atherosclerotic Stroke in a Southern Chinese Han Population.Neuromolecular medicine · 2017Article
- Association between phosphodiesterase 4D (PDE4D) SNP 87 and ischemic stroke: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Genetics of ischemic stroke in young adults.Circulation. Cardiovascular genetics · 2014Review
- Phosphodiesterase 4D single-nucleotide polymorphism 83 and cognitive dysfunction in carotid endarterectomy patients.Neurosurgery · 2013Article
- Compartmentalization of cyclic nucleotide signaling: a question of when, where, and why?Pflugers Archiv : European journal of physiology · 2013Review
- Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.PloS one · 2013Article
- A sequence variant on 17q21 is associated with age at onset and severity of asthma.European journal of human genetics : EJHG · 2010Article
- Genomics of premature atherosclerotic vascular disease.Current atherosclerosis reports · 2010Review
- The genetics of ischaemic stroke.Journal of internal medicine · 2010Review
Corrections and comments
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Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P=3.9 x 10(-6)). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as "STRK1," does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.