ArticleAmerican journal of human genetics2002
Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Inflammatory and Prothrombotic Biomarkers, DNA Polymorphisms, MicroRNAs and Personalized Medicine for Patients with Peripheral Arterial Disease.International journal of molecular sciences · 2022Review
- The Genetic Architecture of the Etiology of Lower Extremity Peripheral Artery Disease: Current Knowledge and Future Challenges in the Era of Genomic Medicine.International journal of molecular sciences · 2022Review
- Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?Life (Basel, Switzerland) · 2022Review
- Association between 1p13 polymorphisms and peripheral arterial disease in a Chinese population with diabetes.Journal of diabetes investigation · 2018Article
- Peripheral Arterial Disease Genetics: Progress to Date and Challenges Ahead.Current cardiology reports · 2017Review
- BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.Circulation · 2017Article
- Biomarkers and Genetics in Peripheral Artery Disease.Clinical chemistry · 2017Review
- The genetic basis of peripheral arterial disease: current knowledge, challenges, and future directions.Circulation research · 2015Review
- Mitochondrial Regulation of the Muscle Microenvironment in Critical Limb Ischemia.Frontiers in physiology · 2015Review
- Mutation in ST6GALNAC5 identified in family with coronary artery disease.Scientific reports · 2014Article
- Therapeutic angiogenesis for critical limb ischaemia.Nature reviews. Cardiology · 2013Review
- Exercise training and peripheral arterial disease.Comprehensive Physiology · 2012Review
- Genetics of peripheral artery disease.Circulation · 2012Review
- Peripheral arterial disease in diabetes: is there a role for genetics?Current diabetes reports · 2011Review
- Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population.Human molecular genetics · 2011Article
- Genomics drugs in clinical trials.Nature reviews. Drug discovery · 2010Article
- SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes.BMC medical genetics · 2010Article
- Genomics of premature atherosclerotic vascular disease.Current atherosclerosis reports · 2010Review
- Admixture mapping of ankle-arm index: identification of a candidate locus associated with peripheral arterial disease.Journal of medical genetics · 2010Article
- A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia.Circulation · 2008Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral arterial occlusive disease (PAOD) results from atherosclerosis of large and medium peripheral arteries, as well as the aorta, and has many risk factors, including smoking, diabetes, hypertension, and hyperlipidemia. PAOD often coexists with coronary artery disease and cerebrovascular disease. Cross-matching a population-based list of Icelandic patients with PAOD who had undergone angiography and/or revascularization procedures with a genealogy database of the entire Icelandic nation defined 116 extended families containing 272 patients. A genomewide scan with microsatellite markers revealed significant linkage to chromosome 1p31 with an allele-sharing LOD score of 3.93 (P=1.04 x 10(-5)). We designate this locus as "PAOD1." Subtracting 35 patients with a history of stroke increased the LOD score to 4.93. This suggests that, although PAOD and other vascular diseases share risk factors, genetic factors specific to subtypes of vascular disease may exist.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.