ReviewMolecular neurobiology
Anterograde axonal transport, transcytosis, and recycling of neurotrophic factors: the concept of trophic currencies in neural networks.
Review in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Brain-Derived Neurotrophic Factor, Nociception, and Pain.Biomolecules · 2024Review
- Mechanisms Controlling the Expression and Secretion of BDNF.Biomolecules · 2023Review
- Neural control of body-plan axis in regenerating planaria.PLoS computational biology · 2019Article
- Article
- Molecular examination of bone marrow stromal cells and chondroitinase ABC-assisted acellular nerve allograft for peripheral nerve regeneration.Experimental and therapeutic medicine · 2016Article
- Simultaneous Detection of Both GDNF and GFRα1 Expression Patterns in the Mouse Central Nervous System.Frontiers in neuroanatomy · 2016Article
- Growth factor choice is critical for successful functionalization of nanoparticles.Frontiers in neuroscience · 2015Article
- Either brain-derived neurotrophic factor or neurotrophin-3 only neurotrophin-producing grafts promote locomotor recovery in untrained spinalized cats.Neurorehabilitation and neural repair · 2015Article
- What can we learn about stroke from retinal ischemia models?Acta pharmacologica Sinica · 2013Review
- NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease.Nanomedicine : nanotechnology, biology, and medicine · 2012Review
- The role of dorsal root ganglia activation and brain-derived neurotrophic factor in multiple sclerosis.Journal of cellular and molecular medicine · 2012Article
- Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases.Molecular neurodegeneration · 2012Article
- The limits of brain determinacy.Proceedings. Biological sciences · 2012Review
- Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT/A).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection.Brain, behavior, and immunity · 2011Article
- The locus ceruleus responds to signaling molecules obtained from the CSF by transfer through tanycytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing.The Journal of biological chemistry · 2011Article
- Trophic factors GDNF and BDNF improve function of retinal sheet transplants.Experimental eye research · 2010Article
- Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Traditional views of neurotrophic factor biology held that trophic factors are released from target cells, retrogradely transported along their axons, and rapidly degraded upon arrival in cell bodies. Increasing evidence indicates that several trophic factors such as brain-derived neurotrophic factor (BDNF), fibroblast growth factor (FGF-2), glial cell-line derived neurotrophic factor (GDNF), insulin-like growth factor (IGF-I), and neurotrophin-3 (NT-3), can move anterogradely along axons. They can escape the degradative pathway upon internalization and are recycled for future uses. Internalized ligands can move through intermediary cells by transcytosis, presumably by endocytosis via endosomes to the Golgi system, by trafficking of the factor to dendrites or by sorting into anterograde axonal transport with subsequent release from axon terminals and uptake by second- or third-order target neurons. Such data suggest the existence of multiple "trophic currencies," which may be used over several steps in neural networks to enable nurturing relationships between connected neurons or glial cells, not unlike currency exchanges between trading partners in the world economy. Functions of multistep transfer of trophic material through neural networks may include regulation of neuronal survival, differentiation of phenotypes and dendritic morphology, synapse plasticity, as well as excitatory neurotransmission. The molecular mechanisms of sorting, trafficking, and release of trophic factors from distinct neuronal compartments are important for an understanding of neurotrophism, but they present challenging tasks owing to the low levels of the endogenous factors.
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Registered trials
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