ArticleProceedings of the National Academy of Sciences of the United States of America2002
Circulating relaxin acts on subfornical organ neurons to stimulate water drinking in the rat.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 106 citations in OpenAlex.
- The mouse pubic symphysis: a narrative review.Frontiers in physiology · 2025Review
- Plasticity in Intrinsic Excitability of Hypothalamic Magnocellular Neurosecretory Neurons in Late-Pregnant and Lactating Rats.International journal of molecular sciences · 2021Article
- Article
- Anatomical Organization of the Rat Subfornical Organ.Frontiers in cellular neuroscience · 2021Article
- The cellular basis of distinct thirst modalities.Nature · 2020Article
- Inhibition of oxytocin and vasopressin neuron activity in rat hypothalamic paraventricular nucleus by relaxin-3-RXFP3 signalling.The Journal of physiology · 2017Article
- Hypothalamic Signaling in Body Fluid Homeostasis and Hypertension.Current hypertension reports · 2017Review
- Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia.Clinical science (London, England : 1979) · 2016Review
- DREADD-induced activation of subfornical organ neurons stimulates thirst and salt appetite.Journal of neurophysiology · 2016Article
- Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients.Psychopharmacology · 2016Article
- Relaxin increases sympathetic nerve activity and activates spinally projecting neurons in the paraventricular nucleus of nonpregnant, but not pregnant, rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Neurohumoral Integration of Cardiovascular Function by the Lamina Terminalis.Current hypertension reports · 2015Review
- Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats.Endocrinology · 2015Article
- International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.Pharmacological reviews · 2015Review
- Hormones and hemodynamics in pregnancy.International journal of endocrinology and metabolism · 2014Review
- Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization.Frontiers in chemistry · 2013Article
- Article
- Relaxin family peptide systems and the central nervous system.Cellular and molecular life sciences : CMLS · 2010Review
- Loss of vitamin D receptor produces polyuria by increasing thirst.Journal of the American Society of Nephrology : JASN · 2008Article
- Adipokines and the blood-brain barrier.Peptides · 2007Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Relaxin, a peptide hormone secreted by the corpus luteum during pregnancy, exerts actions on reproductive tissues such as the pubic symphysis, uterus, and cervix. It may also influence body fluid balance by actions on the brain to stimulate thirst and vasopressin secretion. We mapped the sites in the brain that are activated by i.v. infusion of a dipsogenic dose of relaxin (25 microg/h) by immunohistochemically detecting Fos expression. Relaxin administration resulted in increased Fos expression in the subfornical organ (SFO), organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus, and magnocellular neurons in the supraoptic and paraventricular nuclei. Ablation of the SFO abolished relaxin-induced water drinking, but did not prevent increased Fos expression in the OVLT, supraoptic or paraventricular nuclei. Although ablation of the OVLT did not inhibit relaxin-induced drinking, it did cause a large reduction in Fos expression in the supraoptic nucleus and posterior magnocellular subdivision of the paraventricular nucleus. In vitro single-unit recording of electrical activity of neurons in isolated slices of the SFO showed that relaxin (10(-7) M) added to the perfusion medium caused marked and prolonged increase in neuronal activity. Most of these neurons also responded to 10(-7) M angiotensin II. The data indicate that blood-borne relaxin can directly stimulate neurons in the SFO to initiate water drinking. It is likely that circulating relaxin also stimulates neurons in the OVLT that influence vasopressin secretion. These two circumventricular organs that lack a blood-brain barrier may have regulatory influences on fluid balance during pregnancy in rats.
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