ArticleProceedings of the National Academy of Sciences of the United States of America2002
Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Who cites it
39 citing papers in PubMed, 127 citations in OpenAlex.
- Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions.The Journal of clinical investigation · 2003Trial
- NF-κB/RelA signaling required for CD40-induced humoral immunity depends on specific NEMO lysine residues in mice.The EMBO journal · 2026Article
- Arid2 promotes Follicular B-cell differentiation and antibody responsesbioRxiv : the preprint server for biology · 2025Article
- Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell population expansion.Molecular systems biology · 2025Article
- NF-κB: master regulator of cellular responses in health and disease.Immunity & inflammation · 2025Review
- Transcriptome analysis of Kunming mice responses to the bite of Xenopsylla cheopis.Parasites & vectors · 2024Article
- Article
- Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation.Frontiers in immunology · 2021Review
- Regulatory B cells in cancer.Immunological reviews · 2021Review
- Stimulus-specificity in the Responses of Immune Sentinel Cells.Current opinion in systems biology · 2019Article
- An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration.Materials horizons · 2018Article
- CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Prospects for modulating the CD40/CD40L pathway in the therapy of the hyper-IgM syndrome.Innate immunity · 2018Review
- Mediation of transitional B cell maturation in the absence of functional Bruton's tyrosine kinase.Scientific reports · 2017Article
- CD40-Mediated NF-κB Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Negative role of TAK1 in marginal zone B-cell development incidental to NF-κB noncanonical pathway activation.Immunology and cell biology · 2016Article
- Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model.PLoS pathogens · 2016Article
- Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.PLoS genetics · 2013Article
- Agonistic CD40 antibodies and cancer therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
CD40/CD40L interaction is essential for multiple biological events in T dependent humoral immune responses, including B cell survival and proliferation, germinal center and memory B cell formation, and antibody isotype switching and affinity maturation. By using high-density microarrays, we examined gene expression in primary mouse B lymphocytes after multiple time points of CD40L stimulation. In addition to genes involved in cell survival and growth, which are also induced by other mitogens such as lipopolysaccharide, CD40L specifically activated genes involved in germinal center formation and T cell costimulatory molecules that facilitate T dependent humoral immunity. Next, by examining the roles of individual CD40-activated signal transduction pathways, we dissected the overall CD40-mediated response into genes independently regulated by the individual pathways or collectively by all pathways. We also found that gene down-regulation is a significant part of the overall response and that the p38 pathway plays an important role in this process, whereas the NF-kappa B pathway is important for the up-regulation of primary response genes. Our finding of overlapping independent control of gene expression modules by different pathways suggests, in principle, that distinct biological behaviors that depend on distinct gene expression subsets can be manipulated by targeting specific signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.