ArticleProceedings of the National Academy of Sciences of the United States of America2002
Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 232 citations in OpenAlex.
- The Metabolic Regulation of the NKG2D-Positive NK and T Cells and Their Role in Disease Progression.Biomolecules · 2025Review
- An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding.Cell reports. Medicine · 2025Article
- Emerging roles of natural killer cell ligands-HLA-E, HLA-F, HLA-G, MICA, and MICB-inFrontiers in genetics · 2025Review
- Immune evasion by proteolytic shedding of natural killer group 2, member D ligands inFrontiers in immunology · 2024Article
- Impacts of F18Animals : an open access journal from MDPI · 2023Review
- Article
- Association of non-HLA antibodies against endothelial targets and donor-specific HLA antibodies with antibody-mediated rejection and graft function in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2021Article
- Innate Lymphoid Cells and Natural Killer Cells in Bacterial Infections: Function, Dysregulation, and Therapeutic Targets.Frontiers in cellular and infection microbiology · 2021Review
- Variants at the MHC Region Associate With Susceptibility toFrontiers in immunology · 2021Article
- A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema.Gut microbes · 2020Article
- Overcoming Resistance to Natural Killer Cell Based Immunotherapies for Solid Tumors.Frontiers in oncology · 2019Review
- Bystander T Cells: A Balancing Act of Friends and Foes.Trends in immunology · 2018Review
- Policing the intestinal epithelial barrier: Innate immune functions of intraepithelial lymphocytes.Current pathobiology reports · 2018Article
- Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Sensing Bacterial-Induced DNA Damaging EffectsFrontiers in immunology · 2018Review
- Correlation of serum MMP3 and other biomarkers with clinical outcomes in patients with ankylosing spondylitis: a pilot study.Clinical rheumatology · 2017Article
- Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8Cancer immunology research · 2017Article
- T Cells Infiltrating Diseased Liver Express Ligands for the NKG2D Stress Surveillance System.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Role of major histocompatibility complex variation in graft-versus-host disease after hematopoietic cell transplantation.F1000Research · 2017Review
- How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation.Frontiers in immunology · 2017Review
17 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MICA are distant homologs of MHC class I molecules expressed in the normal intestinal epithelium. They are ligands of the NKG2D activating receptor expressed on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer cells and therefore play a critical role in innate immune responses. We investigated MICA cell-surface expression on infection of epithelial cell lines by enteric bacteria and show here that MICA expression can be markedly increased by bacteria of the diffusely adherent Escherichia coli diarrheagenic group. This effect is mediated by the specific interaction between bacterial adhesin AfaE and its cellular receptor, CD55, or decay-accelerating factor. It is extremely rapid after AfaE binding, consistent with a stress-induced signal. MICA induction on epithelial cells triggered IFN-gamma release by the NKG2D expressing natural killer cell line NKL. This host-bacteria interaction pathway could play a role in the pathogenesis of inflammatory bowel disease, a condition that implicates a bacterial trigger in genetically susceptible individuals. This was supported by the increased MICA expression at the surface of epithelial cells in colonic biopsies from Crohn's disease-affected patients compared with controls.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.