ArticleThe Biochemical journal2002
Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation.
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic disease.European journal of nutrition · 2013Pooled it
- Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study.Lipids in health and disease · 2011Trial
- Phytanic acid, an inconclusive phytol metabolite: A review.Current research in toxicology · 2023Article
- Phytanic acid activates PPARα to promote beige adipogenic differentiation of preadipocytes.The Journal of nutritional biochemistry · 2019Article
- The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes.Nature communications · 2016Article
- Article
- Bhlhe40 Represses PGC-1α Activity on Metabolic Gene Promoters in Myogenic Cells.Molecular and cellular biology · 2015Article
- Lipocalin 2 expression and secretion is highly regulated by metabolic stress, cytokines, and nutrients in adipocytes.PloS one · 2014Article
- Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions.BMC physiology · 2010Article
- PPARs in the Control of Uncoupling Proteins Gene Expression.PPAR research · 2007Article
- Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression.Diabetologia · 2006Article
- In brain mitochondria the branched-chain fatty acid phytanic acid impairs energy transduction and sensitizes for permeability transition.The Biochemical journal · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a phytol-derived branched-chain fatty acid present in dietary products. Phytanic acid increased uncoupling protein-1 (UCP1) mRNA expression in brown adipocytes differentiated in culture. Phytanic acid induced the expression of the UCP1 gene promoter, which was enhanced by co-transfection with a retinoid X receptor (RXR) expression vector but not with other expression vectors driving peroxisome proliferator-activated receptor (PPAR)alpha, PPARgamma or a form of RXR devoid of ligand-dependent sensitivity. The effect of phytanic acid on the UCP1 gene required the 5' enhancer region of the gene and the effects of phytanic acid were mediated in an additive manner by three binding sites for RXR. Moreover, phytanic acid activates brown adipocyte differentiation: long-term exposure of brown preadipocytes to phytanic acid promoted the acquisition of the brown adipocyte morphology and caused a co-ordinate induction of the mRNAs for gene markers of brown adipocyte differentiation, such as UCP1, adipocyte lipid-binding protein aP2, lipoprotein lipase, the glucose transporter GLUT4 or subunit II of cytochrome c oxidase. In conclusion, phytanic acid is a natural product of phytol metabolism that activates brown adipocyte thermogenic function. It constitutes a potential nutritional signal linking dietary status to adaptive thermogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.