ArticleAmerican journal of human genetics2002
Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 78 citations in OpenAlex.
- Lessons from IgA Nephropathy Models.International journal of molecular sciences · 2024Review
- Cyclic neutropenia and concomitant IgA nephropathy: a case report.BMC nephrology · 2023Article
- Treatment strategy with multidrug therapy and tonsillectomy pulse therapy for childhood-onset severe IgA nephropathy.Clinical and experimental nephrology · 2022Review
- TLR9 activation induces aberrant IgA glycosylation via APRIL- and IL-6-mediated pathways in IgA nephropathy.Kidney international · 2020Article
- The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy.Frontiers in immunology · 2016Review
- Genome-wide association study of IgA nephropathy using 23 465 microsatellite markers in a Japanese population.Journal of human genetics · 2015Article
- Polymorphisms in host genes encoding NOSII, C-reactive protein, and adhesion molecules thrombospondin and E-selectin are risk factors for Plasmodium falciparum malaria in India.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Development of Animal Models of Human IgA Nephropathy.Drug discovery today. Disease models · 2014Article
- Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy.PloS one · 2014Article
- Kidney Diseases Enhance Expression of Tetraspanin-8: A Possible Protective Effect against Tubular Injury.Nephron extra · 2014Article
- Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level.BMC medical genetics · 2012Article
- Development of a model of early-onset IgA nephropathy.Journal of the American Society of Nephrology : JASN · 2012Article
- The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese.BMC medical genetics · 2012Article
- Genetics and immunopathogenesis of IgA nephropathy.Clinical reviews in allergy & immunology · 2011Review
- Genomic susceptibility Loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships.Archives of neurology · 2009Article
- IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy.Journal of the American Society of Nephrology : JASN · 2008Article
- The common variants of E-selectin gene in Graves' disease.Genes and immunity · 2008Article
- Variations in the FTO gene are associated with severe obesity in the Japanese.Journal of human genetics · 2008Article
- Functional impact of IgA nephropathy-associated selectin gene haplotype on leukocyte-endothelial interaction.Immunogenetics · 2006Article
- Variants associated with common disease are not unusually differentiated in frequency across populations.American journal of human genetics · 2006Article
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Authors and funding
22 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although intensive efforts have been undertaken to elucidate the genetic background of immunoglobulin A nephropathy (IgAN), genetic factors associated with the pathogenesis of this disease are still not well understood. We designed a case-control association study that was based on linkage disequilibrium among single-nucleotide polymorphisms (SNPs) in the selectin gene cluster on chromosome 1q24-25, and we found two SNPs in the E-selectin gene (SELE8 and SELE13) and six SNPs in the L-selectin gene (SELL1, SELL4, SELL5, SELL6, SELL10, and SELL11) that were significantly associated with IgAN in Japanese patients. All eight SNPs were in almost complete linkage disequilibrium. SELE8 and SELL10 caused amino acid substitutions from His to Tyr and from Pro to Ser (chi2=9.02, P=.0026, odds ratio = 2.73 [95% confidence interval [CI] 1.38--5.38] for His-to-Tyr substitutions; chi2=17.4, P=.000031, odds ratio = 3.61 [95% CI 1.91--6.83] for Pro-to-Ser substitutions), and SELL1 could affect promoter activity of the L-selectin gene (chi2=19.5, P=.000010, odds ratio = 3.77 [95% CI 2.02--7.05]). The TGT haplotype at these three loci was associated significantly with IgAN (chi2=18.67, P=.000016, odds ratio = 1.88 [95% CI 1.41--2.51]). Our results suggest that these eight SNPs in selectin genes may be useful for screening populations susceptible to the IgAN phenotype that involves interstitial infiltration.
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