Evidence map›Paper›PMID 11827987›Full record

ReviewThe Journal of clinical investigation2002

Activation and inhibition of lymphocytes by costimulation.

Kenneth A Frauwirth, Craig B Thompson

Abstract readReview
In one paragraph

Review in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Association Between the CD28 c.17 +3 T>C Polymorphism (rs3116496) and Cancer Risk: An Updated Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Pooled it
  2. Pooled it
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  14. The Role of the CD28 Family Receptors in T-Cell Immunomodulation.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Immune interactions in pembrolizumab (PD-1 inhibitor) cancer therapy and cardiovascular complications.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  20. Review

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kenneth A FrauwirthAbramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.
Craig B Thompson

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ImmunoconjugatesLymphocyte ActivationProtein Serine-Threonine KinasesAbataceptAnimalsAntigens, CDAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteB-LymphocytesCD28 AntigensCTLA-4 AntigenCyclic AMPHumansInducible T-Cell Co-Stimulator ProteinLigandsLymphocytesAbataceptAntigens, CDAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteCD28 AntigensCTLA-4 AntigenCTLA4 protein, humanCtla4 protein, mouseCyclic AMPICOS protein, humanIcos protein, mouseImmunoconjugatesInducible T-Cell Co-Stimulator ProteinLigandsOncogene ProteinsPhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-vavVAV1 protein, humanVav1 protein, mouse

Identifiers

PMID11827987
PMCPMC150864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.