ArticleMolecular and cellular biochemistry2001
Visualization and molecular analysis of nuclear import of protein kinase CK2 subunits in living cells.
Article in Molecular and cellular biochemistry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Interactions with multiple inner kinetochore proteins determine mitotic localization of FACT.The Journal of cell biology · 2025Article
- Okur-Chung neurodevelopmental syndrome-linked CK2α variants have reduced kinase activity.Human genetics · 2021Article
- Demonstration of subcellular migration of CK2α localization from nucleus to sarco(endo)plasmic reticulum in mammalian cardiomyocytes under hyperglycemia.Molecular and cellular biochemistry · 2018Article
- Benzotriazole: An overview on its versatile biological behavior.European journal of medicinal chemistry · 2015Review
- Identification of the phosphorylated residues in TveIF5A by mass spectrometry.Genomics, proteomics & bioinformatics · 2013Article
- Phosphorylation of maize eukaryotic translation initiation factor on Ser2 by catalytic subunit CK2.Molecular and cellular biochemistry · 2011Article
- Isolation of a CK2α subunit and the holoenzyme from the mussel Mytilus galloprovincialis and construction of the CK2α and CK2β cDNAs.Marine biotechnology (New York, N.Y.) · 2011Article
- Protein kinase CK2, an important regulator of the inflammatory response?Journal of molecular medicine (Berlin, Germany) · 2008Review
- Highlighting protein kinase CK2 movement in living cells.Molecular and cellular biochemistry · 2005Article
- The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta.International journal of biological sciences · 2005Article
- Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits.Molecular and cellular biology · 2003Article
- Protein kinase CK2: structure, regulation and role in cellular decisions of life and death.The Biochemical journal · 2003Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have generated fusion proteins between the subunits of CK2 and GFP and characterized their behaviour in living cells. The expressed fusion proteins were functional and interacted with endogenous CK2. Imaging of NIH3T3 cells expressing low level of GFP-CK2alpha or GFP-CK2beta showed that both proteins were mostly nuclear in interphase. Both CK2 subunits contain nuclear localization domains that target them independently to the nucleus. Once in the nucleus, both subunits diffused rapidly in the nucleoplasm. In mitotic cells, CK2 subunits were dispersed throughout the cytoplasm and were not associated to chromatin. Our data are compatible with the idea that each subunit can translocate individually to the nucleus to interact with each other or with important cellular partners. Understanding the molecular mechanisms which regulate the dynamic localization of CK2 subunits will be of central importance.
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Registered trials
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