ArticleMolecular and cellular biochemistry2001
Consequences of CK2 signaling to the nuclear matrix.
Article in Molecular and cellular biochemistry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Demonstration of subcellular migration of CK2α localization from nucleus to sarco(endo)plasmic reticulum in mammalian cardiomyocytes under hyperglycemia.Molecular and cellular biochemistry · 2018Article
- SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.Cell reports · 2017Article
- CK2 Molecular Targeting-Tumor Cell-Specific Delivery of RNAi in Various Models of Cancer.Pharmaceuticals (Basel, Switzerland) · 2017Review
- Protein kinase CK2 inhibition induces cell death via early impact on mitochondrial function.Journal of cellular biochemistry · 2014Article
- Activation of protein kinase CK2 attenuates FOXO3a functioning in a PML-dependent manner: implications in human prostate cancer.Cell death & disease · 2013Article
- Protein kinase CK2 is a critical regulator of epithelial homeostasis in chronic intestinal inflammation.Mucosal immunology · 2013Article
- Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α' subunits reduces orthotopic xenograft prostate tumors in mice.Molecular and cellular biochemistry · 2011Article
- Protein B23/nucleophosmin/numatrin nuclear dynamics in relation to protein kinase CK2 and apoptotic activity in prostate cells.Biochemistry · 2010Article
- Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells.Molecular and cellular biochemistry · 2008Article
- Protein kinase CK2--a key suppressor of apoptosis.Advances in enzyme regulation · 2008Review
- CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity.Molecular and cellular biochemistry · 2007Article
- Regulation of DeltaFosB stability by phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Downregulation of CK2 induces apoptosis in cancer cells--a potential approach to cancer therapy.Molecular and cellular biochemistry · 2005Article
- Modulation of death receptor-mediated apoptosis by CK2.Molecular and cellular biochemistry · 2005Article
- Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization.Investigative ophthalmology & visual science · 2004Article
- Emergence of protein kinase CK2 as a key target in cancer therapy.BioFactors (Oxford, England)Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Protein kinase CK2 is recognized as one of the key cellular signals for cell growth and proliferation. Its nuclear targeting appears to be critical to its role in these functions. In the nucleus, nuclear matrix (NM) which plays a major role in growth-related activities is a primary locus for CK2 signaling. A variety of growth stimuli evoke a rapid translocation of the CK2 to the NM whereas removal of these factors has the opposite effect. These studies, employing various experimental models of cell growth (involving different growth-stimulatory factors), have suggested that rapid shuttling of CK2 to the NM is a key feature of early growth control. By contrast, removal of growth-stimulatory factors leading to the loss of cell viability is associated with early loss of CK2 from the NM (and chromatin). This indicates that absence of CK2 from the nuclear compartment is contributory to induction of cell death via apoptosis, implying a protective role for CK2 against cell death. Here, we review the evidence that suggests that CK2 signaling in the NM is not only involved in cell growth but also in cell survival.
Indexed as
Identifiers
11827176W1558129207What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.