ReviewSpringer seminars in immunopathology2001
Antibody repertoires in infants and adults: effects of T-independent and T-dependent immunizations.
Review in Springer seminars in immunopathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Trial
- Sex-based difference in immune responses and efficacy of the pneumococcal conjugate vaccine.Journal of leukocyte biology · 2024Article
- Intranasal Vaccine Delivery Technology for Respiratory Tract Disease Application with a Special Emphasis on Pneumococcal Disease.Vaccines · 2021Review
- Testing Anti-Pneumococcal Antibody Function Using Bacteria and Primary Neutrophils.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Neutrophils Are Required During Immunization With the Pneumococcal Conjugate Vaccine for Protective Antibody Responses and Host Defense Against Infection.The Journal of infectious diseases · 2020Article
- Targeting Lipooligosaccharide (LOS) for a Gonococcal Vaccine.Frontiers in immunology · 2019Review
- IL-7 Enables Antibody Responses to Bacterial Polysaccharides by Promoting B Cell Receptor Diversity.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Nasopharyngeal Exposure toJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Article
- Decreased production of class-switched antibodies in neonatal B cells is associated with increased expression of miR-181b.PloS one · 2018Article
- Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy.Angewandte Chemie (International ed. in English) · 2017Article
- Challenges in Antibody Development against Tn and Sialyl-Tn Antigens.Biomolecules · 2015Review
- B1b cells recognize protective antigens after natural infection and vaccination.Frontiers in immunology · 2014Review
- Sialyl-tn in cancer: (how) did we miss the target?Biomolecules · 2012Article
- Assessment of T-dependent and T-independent immune responses in cattle using a B cell ELISPOT assay.Veterinary research · 2012Article
- Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide α-1,3 dextran.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis.Arthritis research & therapy · 2008Article
- The kinetics and phenotype of the human B-cell response following immunization with a heptavalent pneumococcal-CRM conjugate vaccine.Immunology · 2006Article
- The role of B cells and accessory cells in the neonatal response to TI-2 antigens.Immunologic research · 2005Review
- C6 test as an indicator of therapy outcome for patients with localized or disseminated lyme borreliosis.Journal of clinical microbiology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Polysaccharide(PS)-encapsulated bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis are among the most prevalent bacterial pathogens of humans. Infections caused by these organisms are both common (otitis media, sinusitis) and severe (meningitis, bacteremia). Antibodies directed against the capsular PS of encapsulated bacteria prevent infection by promoting opsonophagocytic killing. Most bacterial PS, however, are type II T-cell-independent (TI-2) antigens that are poorly immunogenic in young children at highest risk of developing disease. Conjugation of bacterial PS to a protein carrier converts the immune response to a T-cell-dependent (TD) form and significantly improves the immunogenicity of PS, especially in infants. H. influenzae type b (Hib) is a major cause of invasive infection in non-immune children. The medical importance of this pathogen and the availability of both TI-2 and TD Hib PS vaccine formulations have made the human anti-Hib-PS immune response an excellent model for the study of the biology of these B cell responses.
Indexed as
Identifiers
11826616What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.