ArticleThe Plant cell2002
The rice cyclin-dependent kinase-activating kinase R2 regulates S-phase progression.
Article in The Plant cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Regulatory mechanisms and biosynthesis of chlorogenic acid inFrontiers in plant science · 2025Review
- Spermidine augments salt stress resilience in rice roots potentially by enhancing OsbZIP73's RNA binding capacity.BMC plant biology · 2024Article
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- A2-type cyclin is required for the asymmetric entry division in rice stomatal development.Journal of experimental botany · 2018Article
- Studies on growth dynamics of embryogenic cell suspension cultures of commercially important3 Biotech · 2018Article
- Transferring an optimized TAP-toolbox for the isolation of protein complexes to a portfolio of rice tissues.Plant molecular biology · 2016Article
- Quantitative phosphoproteomic analysis of early seed development in rice (Oryza sativa L.).Plant molecular biology · 2016Article
- Characterization of a null allelic mutant of the rice NAL1 gene reveals its role in regulating cell division.PloS one · 2015Article
- In vivo putative O-GlcNAcylation of human SCP1 and evidence for possible role of its N-terminal disordered structure.BMB reports · 2014Article
- Review
- Systemic control of cell division and endoreduplication by NAA and BAP by modulating CDKs in root tip cells of Allium cepa.BioMed research international · 2014Article
- Degradation of MONOCULM 1 by APC/C(TAD1) regulates rice tillering.Nature communications · 2012Article
- A population genomics study of the Arabidopsis core cell cycle genes shows the signature of natural selection.The Plant cell · 2009Article
- Potential roles for autophosphorylation, kinase activity, and abundance of a CDK-activating kinase (Ee;CDKF;1) during growth in leafy spurge.Plant molecular biology · 2007Article
- Arabidopsis kinome: after the casting.Functional & integrative genomics · 2004Review
- Proteome analysis of rice tissues by two-dimensional electrophoresis: an approach to the investigation of gibberellin regulated proteins.Molecular genetics and genomics : MGG · 2004Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclin-dependent kinases (CDKs) are the central components of eukaryotic cell cycle regulation. Phosphorylation of CDKs at a conserved threonine residue is required for their full activity and is mediated by a CDK-activating kinase (CAK). The CAK R2 from rice belongs to those CAKs that phosphorylate not only CDKs but also the C-terminal domain (CTD) of RNA polymerase II. We showed that R2 is a nuclear protein with increased expression and increased CTD kinase activity in S-phase. Increasing R2 abundance through a transgenic approach accelerated S-phase progression and overall growth rate in suspension cells. In planta, the CTD kinase activity of R2 was induced by a growth-promoting signal. R2 regulation, therefore, may constitute a plant-specific adaptive mechanism that is used to adjust the rate of cell proliferation in response to a changing environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.