ArticleThe Journal of physiology2002
Simultaneous imaging of Ca2+ signals in interstitial cells of Cajal and longitudinal smooth muscle cells during rhythmic activity in mouse ileum.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- Changes in interstitial cells of Cajal calcium activity in a diabetic mouse model of delayed gastric emptying.The Journal of physiology · 2026Article
- NMDA Receptors: Next therapeutic targets for Tinnitus?Biochemistry and biophysics reports · 2025Review
- CaPhysiological reviews · 2024Review
- CaCell calcium · 2021Article
- Article
- A myogenic motor pattern in mice lacking myenteric interstitial cells of Cajal explained by a second coupled oscillator network.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles.Advances in experimental medicine and biology · 2019Review
- Regulation of Intracellular Calcium by Endoplasmic Reticulum Proteins in Small Intestinal Interstitial Cells of Cajal.Journal of neurogastroenterology and motility · 2018Article
- Ginsenoside Re inhibits pacemaker potentials via adenosine triphosphate-sensitive potassium channels and the cyclic guanosine monophosphate/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine.Journal of ginseng research · 2015Article
- Ano1, a Ca2+-activated Cl- channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of Cajal.The Journal of physiology · 2014Article
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- Effects of ginsenoside Re on rat jejunal contractility.Journal of natural medicines · 2014Article
- Article
- Smooth muscle cell calcium activation mechanisms.The Journal of physiology · 2008Review
- Effects of imatinib mesylate on spontaneous electrical and mechanical activity in smooth muscle of the guinea-pig stomach.British journal of pharmacology · 2008Article
- Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis.The Journal of physiology · 2007Article
- Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ.The Journal of physiology · 2007Article
- High definition mapping of circular and longitudinal motility in the terminal ileum of the brushtail possum Trichosurus vulpecula with watery and viscous perfusates.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2007Article
- Morphological and physiological evidence for interstitial cell of Cajal-like cells in the guinea pig gallbladder.The Journal of physiology · 2007Article
- Pacemaker phase shift in the absence of neural activity in guinea-pig stomach: a microelectrode array study.The Journal of physiology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrical rhythmicity in smooth muscle cells is essential for the movement of the gastrointestinal tract. Interstitial cells of Cajal (ICC) lie adjacent to smooth muscle layers and are implicated as the pacemaker cells. However, the pace making mechanism remains unclear. To study the intercellular interaction during electrical rhythm generation, we visualized changes in intracellular Ca2+ concentration ([Ca2+]i) in smooth muscle cells and myenteric ICC within segments of mouse ileum loaded with a fluorescent Ca2+ indicator, fluo-3. We observed rhythmic [Ca2+]i changes in longitudinal smooth muscle cells travelling rapidly through the smooth muscle cell layer. Between the rhythmic Ca2+ transients, we found brief Ca2+ transients localized to small areas within smooth muscle cells. The amplitude but not the periodicity of rhythmic [Ca2+]i transients in both cell types was partially inhibited by nicardipine, an L-type Ca2+ channel antagonist, suggesting that the rhythmic [Ca2+]i transients reflect membrane potential depolarizations corresponding to both slow waves and triggered Ca2+ spikes. Longitudinal smooth muscle cells and myenteric ICC showed synchronous spontaneous [Ca2+]i transients in eight out of 21 ileac preparations analysed. In the remaining preparations, the synchrony between ICC and smooth muscle cells was absent, although the rhythmicity of the smooth muscle cells was not disturbed. These results suggest that myenteric ICC may play multiple roles including pace making for physiological bowel movement.
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