ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Mechanisms of the release of anterogradely transported neurotrophin-3 from axon terminals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Substances of Interest That Support Glaucoma Therapy.Nutrients · 2019Review
- Glioactive ATP controls BDNF recycling in cortical astrocytes.Communicative & integrative biology · 2017Article
- Neurotrophin signaling and visceral hypersensitivity.Frontiers in biology · 2014Article
- A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome.Frontiers in cellular neuroscience · 2014Article
- NMDA-dependent switch of proBDNF actions on developing GABAergic synapses.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Anterograde trafficking of neurotrophin-3 in the adult olfactory system in vivo.Experimental neurology · 2013Article
- The role of mesopontine NGF in sleep and wakefulness.Brain research · 2011Article
- BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses.Experimental brain research · 2009Review
- Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Spontaneous glutamatergic activity induces a BDNF-dependent potentiation of GABAergic synapses in the newborn rat hippocampus.The Journal of physiology · 2008Article
- Tumor necrosis factor and stroke: role of the blood-brain barrier.Progress in neurobiology · 2007Review
- Postsynaptic secretion of BDNF and NT-3 from hippocampal neurons depends on calcium calmodulin kinase II signaling and proceeds via delayed fusion pore opening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance.The EMBO journal · 2006Article
- Transcellular induction of neuropeptide Y expression by NT4 and BDNF.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Action potential-evoked and ryanodine-sensitive spontaneous Ca2+ transients at the presynaptic terminal of a developing CNS inhibitory synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Anterograde transport of neurotrophic factors: possible therapeutic implications.Molecular neurobiology · 2004Review
- The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Mechanisms of the release of anterogradely transported neurotrophin-3 from axon terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Sorting of internalized neurotrophins into an endocytic transcytosis pathway via the Golgi system: Ultrastructural analysis in retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Neurotrophins have profound effects on synaptic function and structure. They can be derived from presynaptic, as well as postsynaptic, sites. To date, it has not been possible to measure the release of neurotrophins from axon terminals in intact tissue. We implemented a novel, extremely sensitive assay for the release and transfer of anterogradely transported neurotrophin-3 (NT-3) from a presynaptic to a postsynaptic location that uses synaptosomal fractionation after introduction of radiolabeled NT-3 into the retinotectal projection of chick embryos. Release of the anterogradely transported NT-3 in intact tissue was assessed by measuring the amount remaining in synaptosomal preparations after treatment of whole tecta with pharmacological agents. Use of this assay reveals that release of NT-3 from axon terminals is increased by depolarization, calcium influx via N-type calcium channels, and cAMP analogs, and release is most profoundly increased by excitation with kainic acid or mobilization of calcium from intracellular stores. NT-3 release depends on extracellular sodium, CaM kinase II activity, and requires intact microtubules and microfilaments. Dantrolene inhibits the high potassium-induced release of NT-3, indicating that release of calcium from intracellular stores is required. Tetanus toxin also inhibits NT-3 release, suggesting that intact synaptobrevin or synaptobrevin-like molecules are required for exocytosis. Ultrastructural autoradiography and immunolabel indicate that NT-3 is packaged in presumptive large dense-core vesicles. These data show that release of NT-3 from axon terminals depends on multiple regulatory proteins and ions, including the mobilization of local calcium. The data provide insight in the mechanisms of anterograde neurotrophins as synaptic modulators.
Indexed as
Identifiers
11826122PMC6758481W2147213854What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.