ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Persistent engrailed expression is required to determine sensory axon trajectory, branching, and target choice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Engrailed-1 Promotes Pancreatic Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- TheFrontiers in neural circuits · 2021Review
- Article
- Engrailed homeoproteins in visual system development.Cellular and molecular life sciences : CMLS · 2015Review
- Engrailed alters the specificity of synaptic connections of Drosophila auditory neurons with the giant fiber.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Auditory responses of engrailed and invected-expressing Johnston's Organ neurons in Drosophila melanogaster.PloS one · 2013Article
- En1 and Wnt signaling in midbrain dopaminergic neuronal development.Neural development · 2011Review
- Transcriptional control of behavior: engrailed knock-out changes cockroach escape trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Synapse formation in developing neural circuits.Current topics in developmental biology · 2009Review
- Engrailed expression in subsets of adult Drosophila sensory neurons: an enhancer-trap study.Invertebrate neuroscience : IN · 2008Article
- Pax6 and engrailed 1 regulate two distinct aspects of renshaw cell development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Differential roles of engrailed paralogs in determining sensory axon guidance and synaptic target recognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The transcription factor Engrailed (En) directs, in the cockroach cercal system, the shape of the axonal arborization and the choice of postsynaptic partners of an identified sensory neuron (6m). Knock-out of En using double-stranded RNA interference transforms 6m so that it resembles a neighboring neuron that normally does not express the en gene, has a different arbor anatomy, and makes different connections. We characterized the development of 6m and perturbed en expression at different stages. Our results show that En is not required before birth for 6m to become a neuron, but that it is required in the postmitotic neuron to control axonal arborization and synaptic specificity. Knock-out of En after 6m has entered the CNS does not change the axonal trajectory and has minor effects on axonal branches but causes the formation of synaptic connections typical of an En-negative cell. This suggests that En controls target recognition molecules independently from those guiding the axon. In contrast, double-stranded RNA injection 1 d later does not have any effects on the phenotype of 6m, suggesting that the period of synapse formation is over by the time En levels have fallen or, if synapse turnover occurs, that En is not required to maintain the specificity of synaptic connections. We conclude that persistent en expression is required to determine successive stages in the differentiation of the neuron, suggesting that it is not far upstream from those genes encoding axon guidance and synaptic recognition molecules.
Indexed as
Identifiers
11826113PMC6758474W1959620138What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.