ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Stability and plasticity of developing synapses in hippocampal neuronal cultures.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Dexmedetomidine does not compromise neuronal viability, synaptic connectivity, learning and memory in a rodent model.Scientific reports · 2021Article
- IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids.Redox biology · 2017Article
- Characterizing synaptic protein development in human visual cortex enables alignment of synaptic age with rat visual cortex.Frontiers in neural circuits · 2015Article
- Dynamic mechanisms of neuroligin-dependent presynaptic terminal assembly in living cortical neurons.Neural development · 2014Article
- Comparing development of synaptic proteins in rat visual, somatosensory, and frontal cortex.Frontiers in neural circuits · 2013Article
- The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Use dependence of presynaptic tenacity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Extrasynaptic vesicle recycling in mature hippocampal neurons.Nature communications · 2011Article
- Sensory transduction channel subunits, tax-4 and tax-2, modify presynaptic molecular architecture in C. elegans.PloS one · 2011Article
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- Sharing vesicles between central presynaptic terminals: implications for synaptic function.Frontiers in synaptic neuroscience · 2010Article
- Regulation of CNS synapses by neuronal MHC class I.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Local sharing as a predominant determinant of synaptic matrix molecular dynamics.PLoS biology · 2006Article
- Developmental period for N-methyl-D-aspartate (NMDA) receptor-dependent synapse elimination correlated with visuotopic map refinement.The Journal of comparative neurology · 2006Article
- NMDA receptor currents suppress synapse formation on sprouting axons in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
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Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
To explore mechanisms governing the formation, stability, and elimination of synapses during neuronal development, we used FM 1-43 fluorescence imaging to track vesicle turnover at >7000 individually identified developing synapses between embryonic rat hippocampal neurons in culture. The majority of presynaptic boutons were stable in efficacy and position over a period of 1.5 hr. Activity, evoked by burst-patterned field stimulation, decreased presynaptic function across the population of boutons, an effect that required NMDA receptor activation. Decreased FM 1-43 staining correlated with low synapsin-I and synaptophysin immunoreactivities, suggesting that decreased presynaptic function was commensurate with synaptic disassembly. These observations provide new information on the stability of developing presynaptic function and suggest that NMDA receptor activation may regulate the stability of developing synapses.
Indexed as
Identifiers
11826107PMC6758526What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.