ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Ultrastructure of a somatic spine mat for nicotinic signaling in neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- The application and development of electron microscopy for three-dimensional reconstruction in life science: a review.Cell and tissue research · 2024Review
- An intelligent workflow for sub-nanoscale 3D reconstruction of intact synapses from serial section electron tomography.BMC biology · 2023Article
- 3D Ultrastructure of Synaptic Inputs to Distinct GABAergic Neurons in the Mouse Primary Visual Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Two types of somatic spines provide sites for intercellular signaling during calyx of Held growth and maturation.Synapse (New York, N.Y.) · 2021Article
- Geometric principles of second messenger dynamics in dendritic spines.Scientific reports · 2019Article
- α7-Containing and non-α7-containing nicotinic receptors respond differently to spillover of acetylcholine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Modulation of Ca²⁺ signals by epigallocatechin-3-gallate(EGCG) in cultured rat hippocampal neurons.International journal of molecular sciences · 2011Article
- Systems biology in immunology: a computational modeling perspective.Annual review of immunology · 2011Review
- Lateral mobility of nicotinic acetylcholine receptors on neurons is determined by receptor composition, local domain, and cell type.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Synchronous and asynchronous transmitter release at nicotinic synapses are differentially regulated by postsynaptic PSD-95 proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Multiple cell adhesion molecules shaping a complex nicotinic synapse on neurons.Molecular and cellular neurosciences · 2008Article
- EphB receptors co-distribute with a nicotinic receptor subtype and regulate nicotinic downstream signaling in neurons.Molecular and cellular neurosciences · 2008Article
- Expedited approaches to whole cell electron tomography and organelle mark-up in situ in high-pressure frozen pancreatic islets.Journal of structural biology · 2008Article
- The cell centered database project: an update on building community resources for managing and sharing 3D imaging data.Journal of structural biology · 2008Article
- Cell-autonomous inhibition of alpha 7-containing nicotinic acetylcholine receptors prevents death of parasympathetic neurons during development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Evidence for ectopic neurotransmission at a neuronal synapse.Science (New York, N.Y.) · 2005Article
- Rapid activity-driven SNARE-dependent trafficking of nicotinic receptors on somatic spines.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Development of a model for microphysiological simulations: small nodes of ranvier from peripheral nerves of mice reconstructed by electron tomography.Neuroinformatics · 2005Article
- Transient expression of acetylcholinesterase in the posterior ventral cochlear nucleus of rat brain.Journal of the Association for Research in Otolaryngology : JARO · 2004Article
- Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.Molecular and cellular biology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Chick ciliary neurons have somatic spines grouped in discrete clumps or mats tightly folded against the soma and enriched in nicotinic receptors containing alpha7 subunits. An embryonic ciliary neuron has one to two dozen such spine mats, all overlaid by a large presynaptic calyx engulfing the cell. Three-dimensional tomographic reconstruction from serial thick sections revealed 13 somatic spines in one complete spine mat on a ciliary neuron late in embryogenesis. The spines varied in morphology and usually were branched but had numerous similarities to dendritic spines, including mean length, volume, surface area, presence of endoplasmic reticulum, and occasional multivesicular bodies. The spines invariably were connected to the soma via a narrow neck of approximately 0.2 micrometer in diameter as found for dendritic spines, suggesting restricted access from spine lumen to soma. A prominent difference between dendritic and somatic spines is the absence of postsynaptic densities from most somatic spines both on embryonic and adult ciliary neurons. Transmitter access to receptors on the spines may occur either by lateral diffusion from release sites over nearby postsynaptic densities or by release directly onto spines from the overlying calyx lined with vesicles. The latter is less likely in the adult, where some spines are adjacent to but not overlaid by vesicle-enriched presynaptic structures. The anatomical configuration of spine mats suggests coordinate spine activation by transmitter release into a confined volume while spine morphology is used to control the chemical consequences of synaptic signaling.
Indexed as
Identifiers
11826104PMC6758519W1902144670What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.