ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
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- Dopamine negatively modulates the NCA ion channels in C. elegans.PLoS genetics · 2017Article
- The NCA-1 and NCA-2 Ion Channels Function Downstream of GGenetics · 2017Article
- Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Using melanopsin to study G protein signaling in cortical neurons.Journal of neurophysiology · 2016Article
- Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.Journal of psychopharmacology (Oxford, England) · 2014Article
- Gq rather than G11 preferentially mediates nociceptor sensitization.Molecular pain · 2013Article
- Dendritic generation of mGluR-mediated slow afterdepolarization in layer 5 neurons of prefrontal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Muscarinic receptors modulate the intrinsic excitability of infralimbic neurons and consolidation of fear extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing.Human genetics · 2012Article
- The calcium-activated slow AHP: cutting through the Gordian knot.Frontiers in cellular neuroscience · 2012Article
- Essential role for phosphatidylinositol 4,5-bisphosphate in the expression, regulation, and gating of the slow afterhyperpolarization current in the cerebral cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Dynamic interplay of excitatory and inhibitory coupling modes of neuronal L-type calcium channels.American journal of physiology. Cell physiology · 2011Article
- M1 and M4 receptors modulate hippocampal pyramidal neurons.Journal of neurophysiology · 2011Article
- Cyclic ADP ribose-dependent Ca2+ release by group I metabotropic glutamate receptors in acutely dissociated rat hippocampal neurons.PloS one · 2011Article
- Visinin-like neuronal calcium sensor proteins regulate the slow calcium-activated afterhyperpolarizing current in the rat cerebral cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Excitatory roles of protein kinase C in striatal cholinergic interneurons.Journal of neurophysiology · 2009Article
- Muscarinic ACh receptor-mediated control of thalamic activity via G(q)/G (11)-family G-proteins.Pflugers Archiv : European journal of physiology · 2008Article
- Receptor-specific inhibition of GABAB-activated K+ currents by muscarinic and metabotropic glutamate receptors in immature rat hippocampus.The Journal of physiology · 2007Article
- Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
In hippocampal and other cortical neurons, action potentials are followed by a slow afterhyperpolarization (sAHP) generated by the activation of small-conductance Ca(2+)-activated K(+) channels and controlling spike frequency adaptation. The corresponding current, the apamin-insensitive sI(AHP), is a well known target of modulation by different neurotransmitters, including acetylcholine (via M(3) receptors) and glutamate (via metabotropic glutamate receptor 5, mGluR(5)), in CA1 pyramidal neurons. The actions of muscarinic and mGluR agonists on sI(AHP) involve the activation of pertussis toxin-insensitive G-proteins. However, the pharmacological tools available so far did not permit the identification of the specific G-protein subtypes transducing the effects of M(3) and mGluR(5) on sI(AHP). In the present study, we used mice deficient in the Galpha(q) and Galpha(11) genes to investigate the specific role of these G-protein alpha subunits in the cholinergic and glutamatergic modulation of sI(AHP) in CA1 neurons. In mice lacking Galpha(q), the effects of muscarinic and glutamatergic agonists on sI(AHP) were nearly abolished, whereas beta-adrenergic agonists acting via Galpha(s) were still fully effective. Modulation of sI(AHP) by any of these agonists was instead unchanged in mice lacking Galpha(11). The additional depolarizing effects of muscarinic and glutamatergic agonists on CA1 neurons were preserved in mice lacking Galpha(q) or Galpha(11). Thus, Galpha(q), but not Galpha(11), mediates specifically the action of cholinergic and glutamatergic agonists on sI(AHP), without affecting the modulation of other currents. These results provide to our knowledge one of the first examples of the functional specificity of Galpha(q) and Galpha(11) in central neurons.
Indexed as
Identifiers
11826096PMC6758493W1895032132What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.