ArticleJournal of clinical microbiology2002
Rapid identification of Candida species by confocal Raman microspectroscopy.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Histology-Correlated FTIR Chemical Imaging of Fungal Infection-Associated Tissue Compartments in Human Skin: A Proof-of-Concept Study.Diagnostics (Basel, Switzerland) · 2026Article
- Establishing a competence model in discriminatingBiomedical reports · 2026Article
- The fungal stronghold: biofilms in hemodialysis catheters, diagnostic pitfalls, and the challenge of catheter salvage.Frontiers in cellular and infection microbiology · 2026Review
- Article
- Lighting the Path: Raman Spectroscopy's Journey Through the Microbial Maze.Molecules (Basel, Switzerland) · 2024Article
- Characterization and Differentiation ofPathogens (Basel, Switzerland) · 2024Article
- Applications of Fourier Transform-Infrared spectroscopy in microbial cell biology and environmental microbiology: advances, challenges, and future perspectives.Frontiers in microbiology · 2023Review
- SERS-PLSR Analysis of Vaginal Microflora: Towards the Spectral Library of Microorganisms.International journal of molecular sciences · 2022Article
- Identification of foodborne pathogenic bacteria using confocal Raman microspectroscopy and chemometrics.Frontiers in microbiology · 2022Article
- FTIR and Raman Spectroscopy-Based Biochemical Profiling Reflects Genomic Diversity of ClinicalInternational journal of molecular sciences · 2019Article
- Culture-Free Detection of Crop Pathogens at the Single-Cell Level by Micro-Raman Spectroscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
- Quantitative Raman Spectroscopy Analysis of Polyhydroxyalkanoates Produced by Cupriavidus necator H16.Sensors (Basel, Switzerland) · 2016Article
- Influence of Culture Media on Microbial Fingerprints Using Raman Spectroscopy.Sensors (Basel, Switzerland) · 2015Article
- Raman spectroscopy of microbial pigments.Applied and environmental microbiology · 2014Review
- Comprehensive detection and discrimination of Campylobacter species by use of confocal micro-Raman spectroscopy and multilocus sequence typing.Journal of clinical microbiology · 2012Article
- Evaluation of Escherichia coli cell response to antibiotic treatment by use of Raman spectroscopy with laser tweezers.Journal of clinical microbiology · 2010Article
- Barcoding bacterial cells: A SERS based methodology for pathogen identification.Journal of Raman spectroscopy : JRS · 2008Article
- Raman spectroscopic measurement of relative concentrations in mixtures of oral bacteria.Applied spectroscopy · 2007Article
- Rapid bioparticle concentration and detection by combining a discharge driven vortex with surface enhanced Raman scattering.Biomicrofluidics · 2007Article
- Biology of the pathogenic yeast Candida glabrata.Folia microbiologica · 2006Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida species are important nosocomial pathogens associated with high mortality rates. Rapid detection and identification of Candida species can guide a clinician at an early stage to prescribe antifungal drugs or to adjust empirical therapy when resistant species are isolated. Confocal Raman microspectroscopy is highly suitable for the rapid identification of Candida species, since Raman spectra can be directly obtained from microcolonies on a solid culture medium after only 6 h of culturing. In this study, we have used a set of 42 Candida strains comprising five species that are frequently encountered in clinical microbiology to test the feasibility of the technique for the rapid identification of Candida species. The procedure was started either from a culture on Sabouraud medium or from a positive vial of an automated blood culture system. Prior to Raman measurements, strains were subcultured on Sabouraud medium for 6 h to form microcolonies. Using multivariate statistical analyses, a high prediction accuracy (97 to 100%) was obtained with the Raman method. Identification with Raman microspectroscopy may therefore be significantly faster than identification with commercial identification systems that allow various species to be identified and that often require 24 to 48 h before a reliable identification is obtained. We conclude that confocal Raman microspectroscopy offers a rapid, accurate, and easy-to-use alternative for the identification of clinically relevant Candida species.
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