ArticleJournal of clinical microbiology2002
Identification of four distinct genotypes of Candida dubliniensis and detection of microevolution in vitro and in vivo.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity.Cell chemical biology · 2024Article
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- Exploring the Biology, Virulence, and General Aspects ofInfection and drug resistance · 2024Review
- Clonal evolution ofJournal of oral microbiology · 2021Article
- Lack of detection of Candida nivariensis and Candida bracarensis among 440 clinical Candida glabrata sensu lato isolates in Kuwait.PloS one · 2019Article
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- Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis.Frontiers in microbiology · 2017Review
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- Dynamic time warping assessment of high-resolution melt curves provides a robust metric for fungal identification.PloS one · 2017Article
- Detection of species diversity in oral candida colonization and anti-fungal susceptibility among non-oral habit adult diabetic patients.Journal of natural science, biology, and medicine · 2014Article
- A stable hybrid containing haploid genomes of two obligate diploid Candida species.Eukaryotic cell · 2013Article
- Enrichment of multilocus sequence typing clade 1 with oral Candida albicans isolates in patients with untreated periodontitis.Journal of clinical microbiology · 2012Article
- Candida dubliniensis: an appraisal of its clinical significance as a bloodstream pathogen.PloS one · 2012Article
- First isolation of Candida dubliniensis from oral cavities of dermatological patients in Nanjing, China.Mycopathologia · 2011Article
- Prevalence of Candida dubliniensis fungemia in Argentina: identification by a novel multiplex PCR and comparison of different phenotypic methods.Mycopathologia · 2011Article
- Candida dubliniensis: epidemiology and phenotypic methods for identification.Mycopathologia · 2010Review
- Longitudinal genotyping of Candida dubliniensis isolates reveals strain maintenance, microevolution, and the emergence of itraconazole resistance.Journal of clinical microbiology · 2010Article
- High-throughput identification and quantification of Candida species using high resolution derivative melt analysis of panfungal amplicons.The Journal of molecular diagnostics : JMD · 2010Article
- A Ser29Leu substitution in the cytosine deaminase Fca1p is responsible for clade-specific flucytosine resistance in Candida dubliniensis.Antimicrobial agents and chemotherapy · 2009Article
- Genetic differences between avian and human isolates of Candida dubliniensis.Emerging infectious diseases · 2009Article
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8 authors.
Funding
Abstract
The present study investigates further the population structure of Candida dubliniensis and its ability to exhibit microevolution. Using 98 isolates (including 80 oral isolates) from 94 patients in 15 countries, we confirmed the existence of two distinct populations within the species C. dubliniensis, designated Cd25 group I and Cd25 group II, respectively, on the basis of DNA fingerprints generated with the C. dubliniensis-specific probe Cd25. The majority of Cd25 group I isolates (48 of 71, 67.6%) were from human immunodeficiency virus (HIV)-infected individuals, whereas the majority of Cd25 group II isolates (19 of 27, 70.4%) were from HIV-negative individuals (P < or = 0.001). Nucleotide sequence analysis of the internal transcribed spacer (ITS) regions of the rRNA genes from 19 representative isolates revealed the presence of four separate genotypes. All of the Cd25 group I isolates tested belonged to genotype 1, while the Cd25 group II population was comprised of three distinct genotypes (genotypes 2 to 4), which corresponded to distinct clades within the Cd25 group II population. These findings were confirmed using genotype-specific PCR primers with 70 isolates. We also showed that C. dubliniensis can exhibit microevolution in vivo and in vitro as occurs in other yeast species. DNA fingerprinting using the C. dubliniensis probes Cd25, Cd24, and Cd1 and karyotype analysis of multiple oral isolates recovered from the same specimen from each of eight separate patients revealed microevolution in six of eight of the clonal populations. Similarly, sequential clonal isolates from various anatomical sites in two separate patients exhibited microevolution. Microevolution was also shown to occur when two clinical isolates susceptible to fluconazole were exposed to the drug in vitro. The epidemiological significance of the four C. dubliniensis genotypes and the ability of C. dubliniensis to undergo microevolution has yet to be established.
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