ArticleJournal of clinical pathology2002
Androgen receptor expression in ductal carcinoma in situ of the breast: relation to oestrogen and progesterone receptors.
Article in Journal of clinical pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 53 citations in OpenAlex.
- Targeting microRNA let-7b-5p-mediated aberrant androgen receptor signaling for prevention of hormone receptor-negative breast cancer.NPJ breast cancer · 2026Article
- Hormonal Homologies between Canine Mammary Cancer and Human Breast Cancer in a Series of Cases.Veterinary sciences · 2022Article
- Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer.Iranian journal of pathology · 2020Article
- Androgen and oestrogen receptors as potential prognostic markers for patients with ductal carcinoma in situ treated with surgery and radiotherapy.International journal of experimental pathology · 2017Article
- A Case Report of Adenoid Cystic Carcinoma of Breast- So Close Yet So Far from Triple Negative Breast Cancer.Journal of clinical and diagnostic research : JCDR · 2015Article
- Androgen receptor status predicts response to chemotherapy, not risk of breast cancer in Indian women.World journal of surgical oncology · 2010Article
- Androgens in human breast carcinoma.Medical molecular morphology · 2010Review
- Immunohistochemical categorisation of ductal carcinoma in situ of the breast.British journal of cancer · 2008Article
- Non-operative breast pathology: apocrine lesions.Journal of clinical pathology · 2007Review
- In situ production of sex steroids in human breast carcinoma.Medical molecular morphology · 2007Review
- Immunohistochemical study of androgen receptors in breast carcinoma. Evidence of their frequent expression in lobular carcinoma.Virchows Archiv : an international journal of pathology · 2005Article
- Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer.Journal of cancer research and clinical oncology · 2004Article
- Androgen receptor expression in ductal carcinoma in situ of the breast: relation to oestrogen and progesterone receptors.Journal of clinical pathology · 2002Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimsDuctal carcinoma in situ (DCIS) of the breast has been diagnosed increasingly since the advent of mammographic screening. In contrast to the situation in invasive breast carcinoma, there are no reports on androgen receptor (AR) status in DCIS and few reports on oestrogen (ER) and progesterone (PR) receptors.
methodsAR expression was examined in 57 cases of DCIS of the breast and correlated to the degree of differentiation and ER/PR status using immunohistochemical methods.
resultsAR positivity was noted in 19 of the cases, whereas the other 38 cases were negative. There was no significant association between AR expression and the degree of differentiation of DCIS; three of the 13 well differentiated DCIS cases, 10 of the 19 intermediately differentiated cases, and six of the 25 poorly differentiated cases were positive (p = 0.093). However, a strong association was shown between the expression of ER (p < 0.0001) and PR (p = 0.002) and the degree of differentiation of DCIS. In addition, no significant association was found between the expression of AR and the expression of ER (p = 0.26) or PR (p = 0.57) in DCIS of the breast.
conclusionsA large number of cases of DCIS of the breast express AR and this may be associated with apocrine differentiation, which may impact on accurate typing of DCIS. Moreover, the expression of AR (but not ER or PR) in DCIS does not appear to be associated with the degree of differentiation.
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