ArticleThe EMBO journal2002
A viral protein inhibits the long range signaling activity of the gene silencing signal.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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Who cites it
117 citing papers in PubMed, 329 citations in OpenAlex.
- Cucumber Mosaic Virus Promotes Sphingolipid Biosynthesis to Alleviate Host Unfolded Protein Response (UPR)-Mediated Immunity.Molecular plant pathology · 2026Article
- Silencing Suppressor Protein p26 of Areca Palm Velarivirus 1 (APV1) Interacts With SGS3 and Promotes Its Degradation Via the Ubiquitination Pathway.Molecular plant pathology · 2026Article
- Truncated CMV2bPlant methods · 2025Article
- The non-template functions of helper virus RNAs create optimal replication conditions to enhance the proliferation of satellite RNAs.PLoS pathogens · 2024Article
- Cucumber mosaic virus-induced gene and microRNA silencing in water dropwort (Oenanthe javanica (Blume) DC).Plant methods · 2024Article
- Infection Defects of RNA and DNA Viruses Induced by Antiviral RNA Interference.Microbiology and molecular biology reviews : MMBR · 2023Review
- Engineering resistance against Cucumber mosaic virus in3 Biotech · 2023Article
- Multiple integrations of a sense transgene, including a tandem inverted repeat confer stable RNA-silencing mediated virus resistance under different abiotic and biotic conditions.Transgenic research · 2023Article
- Effect of mutations in the 2b protein of tomato aspermy virus on RNA silencing suppressor activity, virulence, and virus-induced gene silencing.Archives of virology · 2022Article
- Viral suppressor of RNA silencing in vascular plants also interferes with the development of the bryophyte Physcomitrella patens.Plant, cell & environment · 2022Article
- Promoting virus-induced gene silencing of pepper genes by a heterologous viral silencing suppressor.Plant biotechnology journal · 2021Article
- Atypical molecular features of RNA silencing against the phloem-restricted polerovirus TuYV.Nucleic acids research · 2021Article
- Cucumber RDR1s and cucumber mosaic virus suppressor protein 2b association directs host defence in cucumber plants.Molecular plant pathology · 2021Article
- Characterization and evolutionary analysis of Cucumber mosaic virus isolate infecting3 Biotech · 2021Article
- The Weak Small RNA-Binding Activity of the 2b Proteins of Subgroup II Cucumber Mosaic Virus Strains Is Insufficient for RNA Silencing Suppression.Frontiers in microbiology · 2021Article
- Article
- Epigenetics in the plant-virus interaction.Plant cell reports · 2019Review
- Cucumber mosaic virus-induced gene silencing in banana.Scientific reports · 2019Article
- Suppressors of RNA silencing encoded by geminiviruses and associated DNA satellites.Virusdisease · 2019Article
- Transcriptome analysis of two cultivars of tobacco in response to Cucumber mosaic virus infection.Scientific reports · 2019Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-transcriptional gene silencing (PTGS) provides protection against viruses in plants by homology-dependent RNA degradation. PTGS initiated locally produces a mobile signal that instructs specific RNA degradation at a distance. Here we show that this signal-mediated intercellular spread of PTGS does not occur after PTGS initiation in cells expressing cucumber mosaic virus 2b protein (Cmv2b), a nucleus-localized plant viral PTGS suppressor. Silencing spread via the signal was also effectively blocked in independent assays by expressing Cmv2b only in tissues through which the signal must travel to induce PTGS in the target cells. Furthermore, the signal imported externally into the Cmv2b-expressing cells was not active in triggering degradation of the target RNA and loss of signal activity in these cells was associated with a significantly reduced transgene DNA methylation. These findings indicate that Cmv2b inhibits the activity of the mobile signal and interferes with DNA methylation in the nucleus. Signal inactivation provides a mechanistic basis for the known role of Cmv2b in facilitating virus spread to tissues outside of the primarily infected sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.