ArticleThe EMBO journal2002
The dynamin A ring complex: molecular organization and nucleotide-dependent conformational changes.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Long-tailed class I myosins rely on tail-mediated phosphoinositide recognition for specific membrane recruitment.Cell communication and signaling : CCS · 2025Article
- Review
- PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring.Plant physiology · 2020Article
- The structural biology of the dynamin-related proteins: New insights into a diverse, multitalented family.Traffic (Copenhagen, Denmark) · 2019Review
- Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway.Cellular and molecular life sciences : CMLS · 2017Review
- Invited review: Mechanisms of GTP hydrolysis and conformational transitions in the dynamin superfamily.Biopolymers · 2016Review
- Interferon-stimulated genes: a complex web of host defenses.Annual review of immunology · 2014Review
- Crystal structure of nucleotide-free dynamin.Nature · 2011Article
- Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles.Cellular and molecular life sciences : CMLS · 2011Article
- Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.The Journal of biological chemistry · 2010Review
- Article
- The molecular mechanism and cellular functions of mitochondrial division.Biochimica et biophysica acta · 2009Review
- Plastid division: evolution, mechanism and complexity.Annals of botany · 2007Review
- Members of the Arabidopsis dynamin-like gene family, ADL1, are essential for plant cytokinesis and polarized cell growth.The Plant cell · 2003Article
- ARC5, a cytosolic dynamin-like protein from plants, is part of the chloroplast division machinery.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Mitochondrial membrane dynamics are altered in cluA- mutants of Dictyostelium.Journal of muscle research and cell motility · 2002Article
- Neurotransmission and the synaptic vesicle cycle.The Yale journal of biology and medicineReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we show that Dictyostelium discoideum dynamin A is a fast GTPase, binds to negatively charged lipids, and self-assembles into rings and helices in a nucleotide-dependent manner, similar to human dynamin-1. Chemical modification of two cysteine residues, positioned in the middle domain and GTPase effector domain (GED), leads to altered assembly properties and the stabilization of a highly regular ring complex. Single particle analysis of this dynamin A* ring complex led to a three-dimensional map, which shows that the nucleotide-free complex consists of two layers with 11-fold symmetry. Our results reveal the molecular organization of the complex and indicate the importance of the middle domain and GED for the assembly of dynamin family proteins. Nucleotide-dependent changes observed with the unmodified and modified protein support a mechanochemical action of dynamin, in which tightening and stretching of a helix contribute to membrane fission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.