ArticleOncogene2002
Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Methylation of DACT2 promotes papillary thyroid cancer metastasis by activating Wnt signaling.PloS one · 2014Trial
- Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma.Frontiers in oncology · 2020Article
- A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.Molecular cell · 2014Article
- Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.Epigenetics · 2013Article
- Article
- Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- T2 Family ribonucleases: ancient enzymes with diverse roles.Trends in biochemical sciences · 2010Review
- Chromosome 6 encoded RNaseT2 protein is a cell growth regulator.Journal of cellular and molecular medicine · 2010Article
- RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.Nature genetics · 2009Article
- RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer.Oncogene · 2007Article
- The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer.BMC genetics · 2002Article
- Isoforms of Ionotropic Glutamate Receptor GRIK2 Induce Senescence of Carcinoma Cells.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown a high frequency of allele loss at D6S193 (62%) on chromosomal arm 6q27 in ovarian tumours and mapped the minimal region of allele loss between D6S297 and D6S264 (3 cM). We isolated and mapped a single non-chimaeric YAC (17IA12, 260-280 kb) containing D6S193 and D6S297. A further extended bacterial contig (between D6S264 and D6S149) has been established using PACs and BACs and a transcript map has been established. We have mapped six new markers to the YAC; three of them are ESTs (WI-15078, WI-8751, and TCP10). We have isolated three cDNA clones of EST WI-15078 and one clone contains a complete open reading frame. The sequence shows homology to a new member of the ribonuclease family. The other two clones are splice variants of this new gene. The gene is expressed ubiquitously in normal tissues. It is expressed in 4/8 ovarian cancer cell lines by Northern analysis. The gene encodes for a 40 kDa protein. Direct sequencing of the gene in all the eight ovarian cancer cell lines did not identify any mutations. Clonogenic assays were performed by transfecting the full-length gene in to ovarian cancer cell lines and no suppression of growth was observed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.