ArticleWorld journal of gastroenterology2001
Identification of the epitopes on HCV core protein recognized by HLA-A2 restricted cytotoxic T lymphocytes.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Therapeutic polypeptides based on HBcAg(18-27) CTL epitope can induce antigen-specific CD(8)(+) CTL-mediated cytotoxicity in HLA-A2 transgenic mice.World journal of gastroenterology · 2004Article
- Sequence evolution of putative cytotoxic T cell epitopes in NS3 region of hepatitis C virus.World journal of gastroenterology · 2004Article
- Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B.World journal of gastroenterology · 2003Article
- A small yeast RNA inhibits HCV IRES mediated translation and inhibits replication of poliovirus in vivo.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify hepatitis C virus(HCV) core protein epitopes recognized by HLA-A2 restricted cytotoxic T lymphocyte (CTL).
methodsUtilizing the method of computer prediction followed by a 4h(51)Cr release assay confirmation.
resultsThe results showed that peripheral blood mononuclear cells (PBMC) obtained from two HLA-A2 positive donors who were infected with HCV could lyse autologous target cells labeled with peptide "ALAHGVRAL (core 150-158)". The rates of specific lysis of the cells from the two donors were 37.5% and 15.8%, respectively. Blocking of the CTL response with anti-CD4 mAb caused no significant decrease of the specific lysis. But blocking of CTL response with anti-CD8 mAb could abolish the lysis.
conclusionThe peptide (core 150-158) is the candidate epitope recognized by HLAA2 restricted CTL.
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Registered trials
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