ArticleWorld journal of gastroenterology2001
Telomere erosion is independent of microsatellite instability but related to loss of heterozygosity in gastric cancer.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Influence of the hTERT rs2736100 polymorphism on telomere length in gastric cancer.World journal of gastroenterology · 2015Article
- Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer.Oncotarget · 2014Article
- Telomerase at the intersection of cancer and aging.Trends in genetics : TIG · 2013Review
- Telomere attrition in cancer cells and telomere length in tumor stroma cells predict chromosome instability in esophageal squamous cell carcinoma: a genome-wide analysis.Cancer research · 2009Article
- Genetic Mechanisms and Aberrant Gene Expression during the Development of Gastric Intestinal Metaplasia and Adenocarcinoma.Current genomics · 2007Article
- Construction of prokaryotic expression system of 2 148-bp fragment from cagA gene and detection of cagA gene, CagA protein in Helicobacter pylori isolates and its antibody in sera of patients.World journal of gastroenterology · 2004Article
- Construction of a prokaryotic expression system of vacA gene and detection of vacA gene, VacA protein in Helicobacter pylori isolates and ant-VacA antibody in patients' sera.World journal of gastroenterology · 2004Article
- Construction of prokaryotic expression system of ureB gene from a clinical Helicobacter pylori strain and identification of the recombinant protein immunity.World journal of gastroenterology · 2004Article
- Mitochondrial microsatellite instability in gastric cancer and its precancerous lesions.World journal of gastroenterology · 2004Article
- Establishment of Helicobacter pylori infection model in Mongolian gerbils.World journal of gastroenterology · 2004Article
- Expression of pituitary tumor transforming gene in human gastric carcinoma.World journal of gastroenterology · 2004Article
- Nuclear and mitochondrial DNA microsatellite instability in hepatocellular carcinoma in Chinese.World journal of gastroenterology · 2004Article
- Construction of expression systems for flaA and flaB genes of Helicobacter pylori and determination of immunoreactivity and antigenicity of recombinant proteins.World journal of gastroenterology · 2003Article
- Construction of hpaA gene from a clinical isolate of Helicobacter pylori and identification of fusion protein.World journal of gastroenterology · 2003Article
- Effect of ZNRD1 gene antisense RNA on drug resistant gastric cancer cells.World journal of gastroenterology · 2003Article
- Mutation and methylation of hMLH1 in gastric carcinomas with microsatellite instability.World journal of gastroenterology · 2003Article
- Effect of apoptosis on gastric adenocarcinoma cell line SGC-7901 induced by cis-9, trans-11-conjugated linoleic acid.World journal of gastroenterology · 2002Article
- Mutation analysis of APC gene in gastric cancer with microsatellite instability.World journal of gastroenterology · 2002Article
- The role of KDR in the interactions between human gastric carcinoma cell and vascular endothelial cell.World journal of gastroenterology · 2002Article
- Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drug-resistant sublines.World journal of gastroenterology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo correlate the length of the telomere to microsatellite instability (MSI) and loss of heterozygosity (LOH) of APC, MCC and DCC genes in gastric carcinomas.
methodsTelomeric restriction fragment (TRF) length of gastric cancer was measured with Southern blot. LOH of APC, MCC and DCC genes, microsatellite instability (MSI) and frameshift mutation of hMSH6, TGF-betaRII and BAX genes were analyzed by PCR-based methods.
resultsSixty-eight cases of sporadic gastric carcinoma were studied for MSI using five microsatellite markers. MSI in at least one locus was detected in 17 (25%) of 68 tumors analyzed. Frameshift mutations of hMSH6, TGF-betaRII and BAX were detected in 2,6 and 3 of gastric carcinomas respectively showing high MSI (> or = 2 loci, n = 8), but none was found in those showing low MSI (only one locus, n = 9) or MSS (tumor lacking MSI or stable, n = 51). Thirty-five cases, including all high MSI and low MSI, were studied for TRF. The mean TRF length was not correlated with clinicopathological parameters. No association was observed between TRF length and MSI or frameshift mutation. On the contrary, LOH at the DCC locus was related to telomere shortening (P<0.01). This tendency was also observed in APC and MCC genes, although there was no statistical significance.
conclusionThe development of gastric cancer can arise through two different genetic pathways. In high MSI gastric cancers, defective mismatch repair allows mutations to accumulate and generate the high MSI phenotype. In gastric cancers showing either low MSI or MSS, multiple deletions may represent the LOH pathway. Telomere erosion is independent of high MSI phenotype but related to the LOH pathway in gastric cancer.
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