ArticleWorld journal of gastroenterology2001
APC and K-ras gene mutation in aberrant crypt foci of human colon.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Transmission Jeopardy of Adenomatosis Polyposis Coli and Methylenetetrahydrofolate Reductase in Colorectal Cancer.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2021Article
- Molecular Targets in Precision Chemoprevention of Colorectal Cancer: An Update from Pre-Clinical to Clinical Trials.International journal of molecular sciences · 2020Review
- Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer.Disease markers · 2016Article
- Biology of colorectal cancer.Ecancermedicalscience · 2015Review
- Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population.Cancer science · 2009Article
- Abberant crypt foci -- importance in colorectal carcinogenesis and expression of p53 and mdm2: a changing concept.Digestive diseases and sciences · 2008Article
- Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.International journal of cancer · 2008Article
- Histopathological and genetic differences between polypoid and non-polypoid submucosal colorectal carcinoma.World journal of gastroenterology · 2007Article
- Aberrant crypt foci as microscopic precursors of colorectal cancer.World journal of gastroenterology · 2003Review
- Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC.World journal of gastroenterology · 2003Article
- Role of inducible nitric oxide synthase expression in aberrant crypt foci-adenoma-carcinoma sequence.World journal of gastroenterology · 2003Article
- K-ras gene mutation in the diagnosis of ultrasound guided fine-needle biopsy of pancreatic masses.World journal of gastroenterology · 2003Article
- Arterial chemotherapy of 5-fluorouracil and mitomycin C in the treatment of liver metastases of colorectal cancer.World journal of gastroenterology · 2002Article
- Transforming growth factor-beta1 in invasion and metastasis in colorectal cancer.World journal of gastroenterology · 2002Article
- Tumor suppressor gene p16 and Rb expression in gastric cardia precancerous lesions from subjects at a high incidence area in northern China.World journal of gastroenterology · 2002Article
- Rapid screening mitochondrial DNA mutation by using denaturing high-performance liquid chromatography.World journal of gastroenterology · 2002Article
- Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the genetic alteration in ACF and to define the possibility that ACF may be a very early morphological lesion with molecular changes,and to explore the relationship between ACF and colorectal adenoma even carcinoma.
methodsDNA from 35 CRC, 15 adenomas, 34 ACF and 10 normal mucus was isolated by means of microdissection. Direct gene sequencing of K-ras gene including codon 12, 13 and 61 as well as the mutation cluster region (MCR) of APC gene was performed.
resultsK-ras gene mutation frequency in ACF, adenoma and carcinoma was 17.6% (6/34), 13.3% (2/15), and 14.3% (5/35) respectively, showing no difference (P > 0.05) in K-ras gene mutation among three pathologic procedures. The K-ras gene mutation in adenoma, carcinoma and 4 ACF restricted in codon 12 (GGT GAT), but the other 2 mutations from ACF located in codon 13 (GGC GAC). K-ras gene mutation was found more frequently in older patients and patients with polypoid cancer. No mutation in codon 61 was found in the three tissue types. Mutation rate of APC gene in adenoma and carcinoma was 22.9% (8/35) and 26.7% (4/15), which was higher than ACF (2.9%) (P <0.05). APC gene mutation in carcinoma was not correlated with age of patients, location, size and differentiation of tumor.
conclusionACF might be a very early morphological lesion in the tumorogenesis of colorectal tumor. The morphological feature and gene mutation status was different in ACF and adenoma. ACF is possibly putative microadenoma that might be the precursor of adenoma. In addition, the development of a subgroup of colorectal carcinomas might undergo a way of normal epithelium ACF carcinomas .
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