ArticleWorld journal of gastroenterology2001
Expression of nuclear factor-kappa B in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Review
- Short chain fatty acids delay the development of hepatocellular carcinoma in HBx transgenic mice.Neoplasia (New York, N.Y.) · 2021Article
- Interplay Between Non-Canonical NF-κB Signaling and Hepatitis B Virus Infection.Frontiers in immunology · 2021Review
- Hepatitis B virus X protein promotes epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma cell line HCCLM3 by targeting HMGA2.Oncology letters · 2018Article
- Inhibition of hepatitis B virus gene expression & replication by crude destruxins from Metarhizium anisopliae var. dcjhyium.The Indian journal of medical research · 2013Article
- Article
- Identification of genes, including the gene encoding p27Kip1, regulated by serine 276 phosphorylation of the p65 subunit of NF-kappaB.Cancer letters · 2009Article
- Hepatitis B virus X gene induces human telomerase reverse transcriptase mRNA expression in cultured normal human cholangiocytes.World journal of gastroenterology · 2004Article
- Transfection and expression of hepatitis B virus x gene and its effect on apoptosis in HL-7702 cells.World journal of gastroenterology · 2004Article
- Nuclear and mitochondrial DNA microsatellite instability in hepatocellular carcinoma in Chinese.World journal of gastroenterology · 2004Article
- Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma.World journal of gastroenterology · 2004Article
- Expression of NF-kappaB and human telomerase reverse transcriptase in gastric cancer and precancerous lesions.World journal of gastroenterology · 2004Article
- Overexpression of HBxAg in hepatocellular carcinoma and its relationship with Fas/FasL system.World journal of gastroenterology · 2003Article
- Anti-HBV effect of TAT- HBV targeted ribonuclease.World journal of gastroenterology · 2003Article
- The alteration of PTEN tumor suppressor expression and its association with the histopathological features of human primary hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2003Article
- HBV DNA vaccine with adjuvant cytokines induced specific immune responses against HBV infection.World journal of gastroenterology · 2003Article
- Expression of hepatitis B virus X protein in transgenic mice.World journal of gastroenterology · 2003Article
- Anti-inflammatory effect of cholecystokinin and its signal transduction mechanism in endotoxic shock rat.World journal of gastroenterology · 2002Article
- Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice.World journal of gastroenterology · 2002Article
- Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance.World journal of gastroenterology · 2002Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIn this study we investigated the relationship of the X protein of HBV and nuclear factor-kappa B (NF-kappa B) and the expression of NF-kappa B in human hepatocellular carcinoma tissues.
methodsImmunohistochemistry SP method was used to detect the expression of NF-kappa B and the X protein of HBV in human hepatocellular carcinoma tissues of 52 cases. Gene transfection mediated by lipofectamine was used to transfect the eukaryotic expression vector pCDNA3.1-HBX of HBV x gene into human hepatocellular carcinoma cell line HCC-9204 and NF-kappa B was detected.
resultsNF kappa B was widely expressed in human hepatocellular carcinoma tissues in a total of 52 cases and its expression was related to the X protein of HBV. NF-kappa B was localized both in the cytoplasm and the nuclei of hepatocellular carcinoma cells in 11 cases which were positive for the X protein of HBV while in 41 cases negative for the X protein of HBV, NF-kappa B was only localized in the cytoplasm of hepatocellular carcinoma cells but translocated to the nuclei of hepatocellular carcinoma cells after the eukaryotic expression vector pCDNA3.1-HBX was transfected into HCC-9204 cells.
conclusionThis study strongly suggests that the nuclear factor NF-kappa B is widely expressed in hepatocellular carcinoma tissues in different styles according to the expression of the X protein of HBV. NF-kappa B is abnormally activated in hepatocellular carcinoma, which is probably related to the X protein of HBV. The X protein of HBV can activate NF-kappa B to translocate into nuclei of hepatocellular carcinoma cells.
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