ArticleWorld journal of gastroenterology2001
Immunohistochemical study of hepatic oval cells in human chronic viral hepatitis.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Liver progenitor cells perform wound healing in a scratch assay by concerted bistable circuits.NPJ systems biology and applications · 2026Article
- Elevation of tumour markers TGF-β, MBMC cancer · 2017Article
- Ameliorative effect of bone marrow-derived stem cells on injured liver of mice infected with Schistosoma mansoni.The Korean journal of parasitology · 2014Article
- gC1qR expression in normal and pathologic human tissues: differential expression in tissues of epithelial and mesenchymal origin.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- Glutathione-S-transferase subtypes α and π as a tool to predict and monitor graft failure or regeneration in a pilot study of living donor liver transplantation.European journal of medical research · 2011Article
- Possible stem cell origin of human cholangiocarcinoma.World journal of gastroenterology · 2004Article
- Hepatic differentiation capability of rat bone marrow-derived mesenchymal stem cells and hematopoietic stem cells.World journal of gastroenterology · 2004Article
- Inhibitory effect of Huangqi Zhechong decoction on liver fibrosis in rat.World journal of gastroenterology · 2004Article
- Laminin induces the expression of cytokeratin 19 in hepatocellular carcinoma cells growing in culture.World journal of gastroenterology · 2003Article
- A selective tropism of transfused oval cells for liver.World journal of gastroenterology · 2003Article
- Regulating effect of Chinese herbal medicine on the peritoneal lymphatic stomata in enhancing ascites absorption of experimental hepatofibrotic mice.World journal of gastroenterology · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo detect immunohistochemically the presence of oval cells in chronic viral hepatitis with antibody against c-kit.
methodsWe detected oval cells in paraffin embedded liver sections of 3 normal controls and 26 liver samples from patients with chronic viral hepatitis, using immunohistochemistry with antibodies against c-kit, piclass glutathione S-transferase (pi-GST) and cytokeratins 19 (CK19).
resultsOval cells were not observed in normal livers. In chronic viral hepatitis, hepatic oval cells were located predominantly in the periportal region and fibrosis septa,characterized by an ovoid nucleus, small size,and scant cytoplasm. Antibody against stem cell factor receptor, c-kit, had higher sensitivity and specificity than pi-GST and CK19. About 50%-70% of c-kit positive oval cells were stained positively for either pi-GST or CK19.
conclusionOval cells are frequently detected in human livers with chronic viral hepatitis, suggesting that oval cell proliferation is associated with the liver regeneration in this condition.
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