ArticleWorld journal of gastroenterology2001
Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Expression of maspin is associated with the intestinal type of gastric adenocarcinoma.Cancer research and treatment · 2005Article
- Effects of daidzein on estrogen-receptor-positive and negative pancreatic cancer cells in vitro.World journal of gastroenterology · 2004Article
- Detection of micrometastasis of gastric carcinoma in peripheral blood circulation.World journal of gastroenterology · 2004Article
- Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer.World journal of gastroenterology · 2004Article
- Pathobiological behavior and molecular mechanism of signet ring cell carcinoma and mucinous adenocarcinoma of the stomach: a comparative study.World journal of gastroenterology · 2004Article
- Expression of nuclear factor-kappa B and target genes in gastric precancerous lesions and adenocarcinoma: association with Helicobactor pylori cagA (+) infection.World journal of gastroenterology · 2004Article
- Apoptosis of human gastric adenocarcinoma cells induced by beta-ionone.World journal of gastroenterology · 2004Article
- Expression of PCNA and CD44mRNA in colorectal cancer with venous invasion and its relationship to liver metastasis.World journal of gastroenterology · 2003Article
- Variations of mitochondrial D-loop region plus downstream gene 1 2S rRNA-tRNA(phe) and gastric carcinomas.World journal of gastroenterology · 2003Article
- Growth, invasion, metastasis, differentiation, angiogenesis and apoptosis of gastric cancer regulated by expression of PTEN encoding products.World journal of gastroenterology · 2003Article
- Effect of P-selectin monoclonal antibody on metastasis of gastric cancer and immune function.World journal of gastroenterology · 2003Article
- Expression of Fas ligand and caspase-3 contributes to formation of immune escape in gastric cancer.World journal of gastroenterology · 2003Article
- Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa.World journal of gastroenterology · 2003Article
- Expression of estrogen receptor and estrogen receptor messenger RNA in gastric carcinoma tissues.World journal of gastroenterology · 2003Article
- Expression of 1A6 gene and its correlation with intestinal gastric carcinoma.World journal of gastroenterology · 2003Article
- Effect of apoptosis on gastric adenocarcinoma cell line SGC-7901 induced by cis-9, trans-11-conjugated linoleic acid.World journal of gastroenterology · 2002Article
- Mast cell density and the context of clinicopathological parameters and expression of p185, estrogen receptor, and proliferating cell nuclear antigen in gastric carcinoma.World journal of gastroenterology · 2002Article
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7 authors.
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Abstract
aimTo reveal the correlation between the functional differentiation phenotypes of gastric carcinoma cells and the invasion and metastasis by a new way of cell-function classification.
methodsSurgically resected specimens of 361 gastric carcinomas(GC) were investigated with enzyme-, mucin-, and tumor-related marker immunohistochemistry. According to the direction of cell-function differentiation, stomach carcinomas were divided into five functionally differentiated types.
results(1) Absorptive function differentiation type (AFDT): there were 82 (22.7%) patients including 76 (92.7%) aged 45 years. Sixty-nine (84.1%) cases belonged to the intestinal type. Thirty-eight (46.3%) expressed CD44v6 and 9 (13.6%) of 66 male patients developed liver metastasis. The 5-year survival rate of patients in this group (58.5%) was higher than those with the other types (P<0.01). (2) Mucin secreting function differentiation type (MSFDT): 54 (15%) cases. Fifty-three (98.1%) tumors had penetrated the serosa, 12 (22.2%) expressed ER and 22 (40.7%) expressed CD44v6. The postoperative 5-year survival rate was 28.6%. (3) Absorptive and mucin-producing function differentiation type (AMPFDT): there were 180 (49.9%) cases, including 31 (17.2%) aged younger than 45 years. The tumor was more common in women (62, 34.4%,) and expressed more frequently estrogen receptors (ER) (129, 81.7%) than other types (P<0.01). Ovary metastasis was found in 12 (19.4%) out of 62 female subjects. The patients with this type GC had the lowest 5-year survival rate (24.7%) among all types. (4) Specific function differentiation type (SFDT): 13 (3.6%) cases. Nine (69.2%) tumors of this type derived from APUD system, the other 4 (30.7%) were of different histological differentiation. Sixty per cent of the patients survived at least five years. (5) Non-function differentiation type (NFDT): 32 (8.9%) cases. Nineteen (59.4%) cases had lymph node metastases but no one with liver or ovary metastasis. The 5-year survival rate was 28.1%.
conclusionThis new cell-function classification of GC is helpful in indicating the characteristics of invasion and metastasis of GC with different cell-function differentiation phenotypes. Further study is needed to disclose the correlation between the cell-functional differentiation phenotypes and the relevant genotypes and the biological behavior of gastric carcinoma.
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