ArticleWorld journal of gastroenterology2001
The development of colon innervation in trisomy 16 mice and Hirschsprung's disease.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Down syndrome mouse models have an abnormal enteric nervous system.JCI insight · 2019Article
- Murine model of Hirschsprung-associated enterocolitis. I: phenotypic characterization with development of a histopathologic grading system.Journal of pediatric surgery · 2010Article
- Murine model of Hirschsprung-associated enterocolitis II: Surgical correction of aganglionosis does not eliminate enterocolitis.Journal of pediatric surgery · 2010Article
- A novel corrective pullthrough surgery in a mouse model of Hirschsprung's disease.Journal of pediatric surgery · 2009Article
- Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease.Journal of clinical pathology · 2005Article
- Polymerase chain reaction-single strand conformational polymorphism analysis of rearranged during transfection proto-oncogene in Chinese familial Hirschsprung's disease.World journal of gastroenterology · 2005Article
- Clinical relationship between EDN-3 gene, EDNRB gene and Hirschsprung's disease.World journal of gastroenterology · 2003Article
- Mutation of RET gene in Chinese patients with Hirschsprung's disease.World journal of gastroenterology · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the colon innervation of trisomy 16 mouse, an animal model for Down's syndrome, and the expression of protein gene product 9.5 (PGP 9.5) in the stenosed segment of colon in Hirschsprung's disease (HD).
methodsTrisomy 16 mouse breeding;cytogenetic analysis of trisomy 16 mice; and PG P9.5 immunohistochemistry of colons of trisomy 16 mice and HD were carried out.
resultsCompared with their normal littermates, the nervous system of colon in trisomy 16 mice was abnormally developed. There existed developmental delay of muscular plexuses of colon, no submucosal plexus was found in the colon, and there was 5mm aganglionic bowel aparting from the anus in trisomy 16 mice. The mesentery nerve fibers were as well developed as shown in their normal littermates. Abundant proliferation of PGP 9.5 positive nerve fibers was revealed in the stenosed segment of HD colon.
conclusionTrisomy 16 mice could serve as an animal model for Hirschsprung's disease for aganglionic bowel in the distal part of colon. Abundant proliferation of PGP 9.5 positive fibers resulted from extrinsic nerve compensation, since no ganglionic cells were observed in the stenosed segment of the colon in HD. HD has a genetic tendency.
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