ArticleWorld journal of gastroenterology2001
Inhibitory effect and mechanism of acarbose combined with gymnemic acid on maltose absorption in rat intestine.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- In silico analysis of Rutin and Morin against diabetes-associated molecular targets.In silico pharmacology · 2025Article
- A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022Review
- Traditional Indian medicines used for the management of diabetes mellitus.Journal of diabetes research · 2013Review
- Hypoglycemic Effects of Three Medicinal Plants in Experimental Diabetes: Inhibition of Rat Intestinal α-glucosidase and Enhanced Pancreatic Insulin and Cardiac Glut-4 mRNAs Expression.Iranian journal of pharmaceutical research : IJPR · 2013Article
- Antidiabetic properties and mechanism of action of Gynura procumbens water extract in streptozotocin-induced diabetic rats.Molecules (Basel, Switzerland) · 2010Article
- Gymnemic acid interacts with mammalian glycerol-3-phosphate dehydrogenase.Molecular and cellular biochemistry · 2008Article
- Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal.Molecular and cellular biochemistry · 2007Article
- Effects of recombinant human growth hormone on rat septic shock with intraabdominal infection by E. coli.World journal of gastroenterology · 2002Article
- Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats.World journal of gastroenterology · 2001Article
- Inhibitory effect of voglibose and gymnemic acid on maltose absorption in vivo.World journal of gastroenterology · 2001Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare the combinative and individual effect of acarbose and gymnemic acid (GA) on maltose absorption and hydrolysis in small intestine to determine whether nutrient control in diabetic care can be improved by combination of them.
methodsThe absorption and hydrolysis of maltose were studied by cyclic perfusion of intestinal loops in situ and motility of the intestine was recorded with the intestinal ring in vitro using Wistar rats.
resultsThe total inhibitory rate of maltose absorption was improved by the combination of GA (0.1g/L-1.0 g/L) and acarbose (0.1 mmol/L-2.0 mmol/L) throughout their effective duration (P <0.05, U test of Mann-Whitney), although the improvement only could be seen at a low dosage during the first hour. With the combination, inhibitory duration of acarbose on maltose absorption was prolonged to 3h and the inhibitory effect onset of GA was fastened to 15 min. GA suppressed the intestinal mobility with a good correlation (r = 0.98) to the inhibitory effect of GA on maltose absorption and the inhibitory effect of 2 mmol/L (high dose) acarbose on maltose hydrolysis was dual modulated by 1g/L GA in vivo indicating that the combined effects involved the functional alteration of intestinal barriers.
conclusionThere are augmented effects of acarbose and GA,which involve pre-cellular and paracellular barriers. Diabetic care can be improved by employing the combination.
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