ArticleWorld journal of gastroenterology2000
Effect of hepatocyte apoptosis induced by TNF-alpha on acute severe hepatitis in mouse models.
Article in World journal of gastroenterology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
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- Effect of mitoTEMPO on Redox Reactions in Different Body Compartments upon Endotoxemia in Rats.Biomolecules · 2023Article
- Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure.Frontiers in cellular and infection microbiology · 2021Article
- Article
- Telmisartan Ameliorates Astroglial and Dopaminergic Functions in a Mouse Model of Chronic Parkinsonism.Neurotoxicity research · 2018Article
- Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice.Stem cells translational medicine · 2017Article
- In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice.Disease models & mechanisms · 2014Article
- Glycyrrhizic acid in the treatment of liver diseases: literature review.BioMed research international · 2014Review
- An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models.Molecular therapy : the journal of the American Society of Gene Therapy · 2008Article
- Tumor necrosis factor alpha antibody prevents brain damage of rats with acute necrotizing pancreatitis.World journal of gastroenterology · 2004Article
- FR167653 attenuates murine immunological liver injury.World journal of gastroenterology · 2004Article
- Inhibition of Fas/FasL mRNA expression and TNF-alpha release in concanavalin A-induced liver injury in mice by bicyclol.World journal of gastroenterology · 2004Article
- The protective mechanism of Yisheng Injection against hepatic ischemia reperfusion injury in mice.World journal of gastroenterology · 2004Article
- Signal transduction of gap junctional genes, connexin32, connexin43 in human hepatocarcinogenesis.World journal of gastroenterology · 2003Article
- Effect of leflunomide on immunological liver injury in mice.World journal of gastroenterology · 2003Article
- The analysis of gamma-glutamyl transpeptidase gene in different type liver tissues.World journal of gastroenterology · 2003Article
- Effects of electroporation on primary rat hepatocytes in vitro.World journal of gastroenterology · 2002Article
- Preparation of monoclonal antibody against apoptosis-associated antigens of hepatoma cells by subtractive immunization.World journal of gastroenterology · 2002Article
- Regulating effect of Chinese herbal medicine on the peritoneal lymphatic stomata in enhancing ascites absorption of experimental hepatofibrotic mice.World journal of gastroenterology · 2002Article
- CCK-8 inhibits expression of TNF-alpha in the spleen of endotoxic shock rats and signal transduction mechanism of p38 MAPK.World journal of gastroenterology · 2002Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the effect of hepatocyte apoptosis and necrosis induced by TNF-alpha on the pathogenesis of acute severe hepatitis (ASH).
methodsThe model of ASH was prepared in D-galactosamine (GalN) sensitized BALB/c mice by injection of either endotoxin (ET) or tumor necrosis factor-alpha(TNF-alpha. Morphological changes of apoptotic hepatocytes were studied by both light and electron microscope and in site end labeling method (ISEL). Molecular biological changes of DNA ladder were observed by electrophoresis of extract from liver tissues. Biochemical changes were measured by alanine aminotransferase (ALT), aspartic aminotransferase (AST) and TNF-alpha. The relation between apoptosis and necrosis was evaluated simultaneously.
resultsThe sequence of hepatocyte apoptosis, necrosis, and final death from ASH was observed both in GalN/ET and GalN/TNF-alpha group. Apoptosis was prominent at 3.5h and 6h after injection of inducer, while necrosis became dominant at 9h after challenge. The appearance of apoptosis was earlier in GalN/TNF-alpha group than that in GalN/ET group. Pretreatment of mice with antiTNF IgG1 may completely prevent the liver injury induced by GalN/ET.
conclusionTNF-alpha can cause liver amage by inducing hepatic apoptosis and necrosis in mice with endotoxemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.