ArticleWorld journal of gastroenterology2000
Glyco-poly-l-lysine is better than liposomal delivery of exogenous genes to rat of liver.
Article in World journal of gastroenterology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Nano-vectors for efficient liver specific gene transfer.International journal of nanomedicine · 2008Review
- Distribution and anti-HBV effects of antisense oligodeoxynucleotides conjugated to galactosylated poly-L-lysine.World journal of gastroenterology · 2003Article
- Angiogenesis effect on rat liver after administration of expression vector encoding vascular endothelial growth factor D.World journal of gastroenterology · 2003Article
- Expression of exogenous rat collagenase in vitro and in a rat model of liver fibrosis.World journal of gastroenterology · 2002Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare the effects of liposomes and glyco-poly-L-lysine on liver targeted uptake and expression of plasmid in rat liver.
methodsAfter binding with lipofectamine or galactose-terminal glyco-poly-l-lysine, the plasmid could be expressed in eukaryotic cells when injected in to Wistar rats by intravenous route. At different time intervals after the injection, the distribution and expression of the plasmid in liver of rats were observed and compared using in situ hybridization and immunohistochemistry.
resultsThe expression of the plasmidbinding to liposomes or G-PLL cou ld be markedly observed 24 h later, and began to decrease one week later,but it still could be observed up to three weeks.Both liposomes and G-PLL coul d deliver the plasmid to the liver effectively, but the effect of the latter was better than the former concerning the distribution and expression of the plasmid targeted uptake in the liver.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.