ArticleWorld journal of gastroenterology1999
Pathogenic effects of Opolysaccharide from Shigella flexneri strain.
Article in World journal of gastroenterology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis.World journal of gastroenterology · 2001Trial
- Article
- Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.Clinical microbiology reviews · 2008Review
- Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a.BMC genomics · 2006Article
- Identification of alkA gene related to virulence of Shigella flexneri 2a by mutational analysis.World journal of gastroenterology · 2003Article
- Identification of RanBMP interacting with Shigella flexneri IpaC invasin by two-hybrid system of yeast.World journal of gastroenterology · 2003Article
- Distribution of nitric oxide synthase in stomach myenteric plexus of rats.World journal of gastroenterology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the specific pathogenesis of O-polysaccharide (O-PS) which is on the outer membrane of lipopolysaccharides (LPS) from Shigella flexneri.
methodsThe O-PS was isolated and purified from Shigella flexneri 5 M90T by enzymatic hydrolysis and gel chromatography. Effects of O-PS were observed by in vitro experiment, (HeLa cell culture), and in vivo experiment (rabbit ileal loop assay).
resultsIn vitro and in vivo experiments with the purified O-PS from Shigella flexneri revealed that the O-PS alone was toxic to Hela cells and caused mucosal inflammation and hemorrhagic exudation in ileal loop of rabbit.DISCUSSION:O-PS might be one of the factors causing diarrhea and its mechanism was different from endotoxin reaction of LPS.The molecular mechanism of O-PS need further studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.